HLA and NK Cell Inhibitory Receptor Genes in Resolving Hepatitis C Virus Infection

Natural killer (NK) cells provide a central defense against viral infection by using inhibitory and activation receptors for major histocompatibility complex class I molecules as a means of controlling their activity. We show that genes encoding the inhibitory NK cell receptor KIR2DL3 and its human...

Full description

Saved in:

Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 305; no. 5685; pp. 872 - 874
Main Authors:	Khakoo, Salim I., Thio, Chloe L., Martin, Maureen P., Brooks, Collin R., Gao, Xiaojiang, Astemborski, Jacquie, Cheng, Jie, Goedert, James J., Vlahov, David, Hilgartner, Margaret, Cox, Steven, Little, Ann-Margeret, Alexander, Graeme J., Cramp, Matthew E., O'Brien, Stephen J., William M. C. Rosenberg, Thomas, David L., Carrington, Mary
Format:	Journal Article
Language:	English
Published:	Washington, DC American Association for the Advancement of Science 06-08-2004 The American Association for the Advancement of Science
Subjects:	Adolescent Adult African Americans African Americans - genetics Alleles Antigens Biological and medical sciences Blood Transfusion Cells Child Cohort Studies Drug Use European Continental Ancestry Group - genetics Female Genes Genetic aspects Genotypes Hepacivirus - immunology Hepacivirus - physiology Hepatitis Hepatitis C Hepatitis C - genetics Hepatitis C - immunology Hepatitis C - transmission Hepatitis C - virology Hepatitis C virus HLA antigens HLA C antigens HLA-C Antigens - genetics HLA-C Antigens - immunology HLA-C Antigens - metabolism Homozygote Human viral diseases Humans Immune system Infections Infectious diseases Killer Cells, Natural - immunology Ligands Male Medical sciences Natural killer cells Physiological aspects Protective effects Receptors Receptors, Immunologic - genetics Receptors, Immunologic - metabolism Receptors, KIR Receptors, KIR2DL1 Receptors, KIR2DL3 Regression Analysis Viral diseases Viral hepatitis Viruses Whites Human HLA-System Immune response Major histocompatibility system Hepatic disease Cell cell interaction Cellular immunity Host virus relation Infection Virus Natural killer cell Viral disease Digestive diseases Flaviviridae Hepatitis C virus Hepacivirus Viral hepatitis C Biological receptor
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!