Large-Scale Sprouting of Cortical Connections After Peripheral Injury in Adult Macaque Monkeys

• Published in: Science (American Association for the Advancement of Science) Vol. 282; no. 5391; pp. 1117 - 1121
• Main Authors: Florence, Sherre L., Taub, Hilary B., Kaas, John H.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 06-11-1998; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Amputation; Animals; Arm; Arm - innervation; Arm Injuries - pathology; Arm Injuries - physiopathology; Axons; Biological and medical sciences; Brain; Brain Mapping; Development. Senescence. Regeneration. Transplantation; Electrophysiology; Face; Face - innervation; Forelimbs; Fundamental and applied biological sciences. Psychology; Hands; Higher nervous activity; Injuries; Macaca; Microelectrodes; Monkeys; Monkeys & apes; Neural Pathways - physiology; Neurology; Neurons; Neurons, Afferent - physiology; Physical Disabilities; Somatosensory cortex; Somatosensory Cortex - pathology; Somatosensory Cortex - physiopathology; Sprouting; Stimulation; Thalamus - pathology; Thalamus - physiopathology; Vertebrates: nervous system and sense organs; Wrist; Nervous system diseases; Growth; Central nervous system; Monkey; Anatomy; Somatosensory cortex; Regeneration; Vertebrata; Somatotopy; Mammalia; Pain; Somesthetic pathway; Amputation; Primates; Neurological disorder; Phantom limb; Brain (vertebrata)
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.282.5391.1117

Distributions of thalamic and cortical connections were investigated in four macaque monkeys with long-standing, accidental trauma to a forelimb, to determine whether the growth of new connections plays a role in the reorganization of somatosensory cortex that occurs after major alterations in peripheral somatosensory inputs. In each monkey, microelectrode recordings of cortical areas 3b and 1 demonstrated massive reorganizations of the cortex related to the affected limb. Injections of tracers in area 1 of these monkeys revealed normal patterns of thalamocortical connections, but markedly expanded lateral connections in areas 3b and 1. Thus, the growth of intracortical but not thalamocortical connections could account for much of the reorganization of the sensory maps in cortex.