Circulating mitochondrial DAMPs cause inflammatory responses to injury

Injury causes a systemic inflammatory response syndrome (SIRS) that is clinically much like sepsis. Microbial pathogen-associated molecular patterns (PAMPs) activate innate immunocytes through pattern recognition receptors. Similarly, cellular injury can release endogenous ‘damage’-associated molecu...

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Bibliographic Details
Published in:	Nature Vol. 464; no. 7285; pp. 104 - 107
Main Authors:	Zhang, Qin, Itagaki, Kiyoshi, Raoof, Mustafa, Sursal, Tolga, Sumi, Yuka, Junger, Wolfgang, Chen, Yu, Hauser, Carl J, Brohi, Karim
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04-03-2010 Nature Publishing Group
Subjects:	631/208/726/2129 692/420/256 692/420/2780/262 692/699/578 Acute Lung Injury - immunology Acute Lung Injury - pathology Animals Bacterial proteins Biological and medical sciences Calcium Signaling Cells, Cultured CpG Islands - immunology Deoxyribonucleic acid DNA DNA, Mitochondrial - blood DNA, Mitochondrial - immunology Femur - injuries Fractures Fractures, Bone - immunology Fractures, Bone - pathology Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Humans Immunity, Innate - immunology Infection Inflammation letter Liver - immunology Liver - injuries Liver - pathology Male Mitochondria - immunology Mitochondria - secretion Mitochondrial DNA Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology multidisciplinary Muscle, Skeletal - immunology Muscle, Skeletal - pathology N-Formylmethionine Leucyl-Phenylalanine - immunology N-Formylmethionine Leucyl-Phenylalanine - metabolism Neutrophils - enzymology Neutrophils - immunology Neutrophils - metabolism Pattern recognition Peptides Phosphorylation Physiological aspects Rats Rats, Sprague-Dawley Receptors, Formyl Peptide - metabolism Rheumatoid arthritis Risk factors Science Science (multidisciplinary) Sepsis - immunology Sepsis - metabolism Sepsis - microbiology Systemic Inflammatory Response Syndrome - blood Systemic Inflammatory Response Syndrome - complications Systemic Inflammatory Response Syndrome - immunology Systemic Inflammatory Response Syndrome - pathology Toll-Like Receptor 9 - metabolism Trauma Wounds and Injuries - blood Wounds and Injuries - complications Wounds and Injuries - immunology Wounds and Injuries - pathology United Kingdom Natural immunity Mitochondria Inflammation Immune response Immunity Pathogen Associated Molecular Patterns
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