Chronological Volume Changes of the Temporal Muscle Pedicle Used for Encephalo-myo-synangiosis in Combined Revascularization for Moyamoya Disease: A Prospective Observational Study

• Published in: Neurologia Medico-Chirurgica Vol. 63; no. 7; pp. 304 - 312
• Main Authors: MIZUSHIMA, Makoto, ITO, Masaki, FUJIMA, Noriyuki, UCHINO, Haruto, SUGIYAMA, Taku, FUJIMURA, Miki
• Format: Journal Article
• Language: English
• Published: Japan The Japan Neurosurgical Society 15-07-2023; THE JAPAN NEUROSURGICAL SOCIETY; Japan Science and Technology Agency
• Subjects: Angiography; Blood flow; Cerebral blood flow; Cerebral Revascularization - adverse effects; Cerebral Revascularization - methods; Compression; Computed tomography; encephalo-myo-synangiosis; Humans; Magnetic Resonance Angiography - methods; Moyamoya disease; Moyamoya Disease - complications; Moyamoya Disease - diagnostic imaging; Moyamoya Disease - surgery; Observational studies; Original; Patients; Surgery; swollen temporal muscle; Temporal Muscle - surgery; time-course; Treatment Outcome; vascular disorder; encephalo-myo-synangiosis; swollen temporal muscle; vascular disorder; Moyamoya disease; time-course
• ISSN: 0470-8105; 1349-8029
• DOI: 10.2176/jns-nmc.2023-0008

Although postoperative neurological events due to brain compression by the swollen temporal muscle are a rare complication, the chronological volume changes of the temporal muscle pedicle and their clinical impact have not yet been documented. This prospective observational study aimed to investigate the chronological volume changes in the temporal muscle pedicle in Moyamoya disease (MMD). Eighteen consecutive combined revascularization procedures using the temporal muscle were performed for symptomatic MMD in 2021. The postoperative pedicle volume was quantified using repeated computed tomography images on postoperative days (PODs) 0, 1, 7, 14, and 30. Postoperative neurological events with radiological evaluations and collateral development evaluated using magnetic resonance angiography obtained 6 months after surgery were studied. On average, the postoperative temporal muscle pedicle volume was most significantly increased by as much as 112% ± 9.6% on POD 7 (P < 0.001) and decreased by as little as 52% ± 21% on POD 30 (P < 0.0001) relative to POD 0. One exceptional patient (overall incidence, 5.6%) demonstrated postoperative transient neurological events due to brain compression by the swollen temporal muscle with decreased focal cerebral blood flow in the adjacent cortical area. The postoperative collateral development via direct and indirect revascularizations was confirmed in 16 (89%) and 12 (67%) hemispheres, respectively. All patients, except for one rebleeding case, showed independent outcomes at the mean latest follow-up period on 290 ± 96 days after surgery. Our observations confirmed the temporal profile of muscle pedicle volume changes after combined revascularization. Through routine attempts to avoid the unfavorable effects of temporal muscle swelling, combined revascularization can provide favorable outcomes in symptomatic MMD.