Experimental Treatment of Ebola Virus Disease with TKM-130803: A Single-Arm Phase 2 Clinical Trial

TKM-130803, a small interfering RNA lipid nanoparticle product, has been developed for the treatment of Ebola virus disease (EVD), but its efficacy and safety in humans has not been evaluated. In this single-arm phase 2 trial, adults with laboratory-confirmed EVD received 0.3 mg/kg of TKM-130803 by...

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Published in:	PLoS medicine Vol. 13; no. 4; p. e1001997
Main Authors:	Dunning, Jake, Sahr, Foday, Rojek, Amanda, Gannon, Fiona, Carson, Gail, Idriss, Baimba, Massaquoi, Thomas, Gandi, Regina, Joseph, Sebatu, Osman, Hassan K, Brooks, Timothy J G, Simpson, Andrew J H, Goodfellow, Ian, Thorne, Lucy, Arias, Armando, Merson, Laura, Castle, Lyndsey, Howell-Jones, Rebecca, Pardinaz-Solis, Raul, Hope-Gill, Benjamin, Ferri, Mauricio, Grove, Jennifer, Kowalski, Mark, Stepniewska, Kasia, Lang, Trudie, Whitehead, John, Olliaro, Piero, Samai, Mohammed, Horby, Peter W
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 19-04-2016 Public Library of Science (PLoS)
Subjects:	Adult Aged Aged, 80 and over Antiviral agents Antiviral Agents - therapeutic use Biology and Life Sciences Body fluids Clinical trials Drug dosages Drug therapy Ebola hemorrhagic fever Ebola virus Ebolavirus - genetics Ebolavirus - pathogenicity Enrollments Female Health aspects Hemorrhagic Fever, Ebola - diagnosis Hemorrhagic Fever, Ebola - drug therapy Hemorrhagic Fever, Ebola - genetics Hemorrhagic Fever, Ebola - mortality Hemorrhagic Fever, Ebola - virology Host-Pathogen Interactions Humans Infusions, Intravenous Laboratories Male Medicine and Health Sciences Middle Aged Nanoparticles Patients Research and analysis methods Researchers RNA, Small Interfering - administration & dosage RNA, Small Interfering - therapeutic use RNA, Viral - blood RNA, Viral - genetics RNAi Therapeutics - adverse effects RNAi Therapeutics - methods Sierra Leone Studies Survival Analysis Time Factors Treatment Outcome Viral Load - drug effects Viral Load - genetics Young Adult Sierra Leone United Kingdom Ireland West Africa
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