Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription- Dependent and -Independent Mechanisms

A mechanism by which the Ras-mitogen-activated protein kinase (MAPK) signaling pathway mediates growth factor-dependent cell survival was characterized. The MAPK-activated kinases, the Rsks, catalyzed the phosphorylation of the pro-apoptotic protein BAD at serine 112 both in vitro and in vivo. The R...

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Bibliographic Details
Published in:	Science (American Association for the Advancement of Science) Vol. 286; no. 5443; pp. 1358 - 1362
Main Authors:	Bonni, Azad, Brunet, Anne, West, Anne E., Datta, Sandeep Robert, Takasu, Mari A., Greenberg, Michael E.
Format:	Journal Article
Language:	English
Published:	Washington, DC American Society for the Advancement of Science 12-11-1999 American Association for the Advancement of Science The American Association for the Advancement of Science
Subjects:	Animals Antibodies Apoptosis bcl-Associated Death Protein Biological and medical sciences Brain-Derived Neurotrophic Factor - pharmacology Carrier Proteins - genetics Carrier Proteins - metabolism Cell death Cell growth Cell physiology Cell Survival Cells Cells, Cultured Cellular biology Cerebellum - cytology Cyclic AMP Response Element-Binding Protein - metabolism Enzyme Activation Enzyme Inhibitors - pharmacology Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Genes Immunoblotting Inhibition Insulin-Like Growth Factor I - pharmacology MAP Kinase Kinase 1 MAP Kinase Signaling System Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinase Kinases - metabolism Mitogen-Activated Protein Kinases - antagonists & inhibitors Mitogen-Activated Protein Kinases - metabolism Molecular and cellular biology Mutation Neurons Neurons - cytology Neurons - metabolism Neuroscience Phosphorylation Phosphoserine - metabolism Plasmids Protein kinases Protein-Serine-Threonine Kinases Proteins ras Proteins - metabolism Rats Rats, Long-Evans Recombinant Fusion Proteins - metabolism Ribosomal Protein S6 Kinases - genetics Ribosomal Protein S6 Kinases - metabolism Signal transduction Transcription, Genetic Transfection Human Phosphorylation Enzyme Transferases Serine Survival Protein Kidney Signal transduction Cell line Neuron Gene Protein kinase Cell Transcription factor CREB Apoptosis
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