Sol–gel‐derived bioactive glass containing SiO 2 –MgO–CaO–P 2 O 5 as an antibacterial scaffold

• Published in: Journal of biomedical materials research. Part A Vol. 101A; no. 6; pp. 1582 - 1587
• Main Authors: Imani Fooladi, Abbas Ali, Hosseini, Hamideh Mahmoodzadeh, Hafezi, Forough, Hosseinnejad, Fatemeh, Nourani, Mohammad Reza
• Format: Journal Article
• Language: English
• Published: 01-06-2013
• ISSN: 1549-3296; 1552-4965
• DOI: 10.1002/jbm.a.34464

Bioactive glass (BG) composites with a base of SiO
2
–Na
2
O–CaO–P
2
O
5
are biocompatible biomaterials. The assessment of their abilities for medical applications has interested researchers. We produced a BG‐containing SiO
2
–MgO–CaO–P
2
O
5
by the sol–gel method. To determine the antibacterial effects, we analyzed the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) properties of this product on three microorganisms,
Staphylococcus aureus
,
Escherichia coli
and
Pseudomonas aeruginosa
, known causative agents for biofilm formation on implant surfaces. In addition, we performed the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay to study the cytotoxic effects of our composite on animal cells. Our results demonstrated that our BG product inhibited the growth of bacteria in a concentration‐dependent manner without any cytotoxic effects. Therefore, our BG product can be utilized as an appropriate implant for treating bone and tooth defects. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2013.