Pineal Opsin: A Nonvisual Opsin Expressed in Chick Pineal
Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 267; no. 5203; pp. 1502 - 1506 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Washington, DC
American Society for the Advancement of Science
10-03-1995
American Association for the Advancement of Science The American Association for the Advancement of Science |
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| Abstract | Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46 percent identical to that of the retinal opsins. P-opsin is a seven-membrane spanning, G protein-linked receptor with a Schiff-base lysine in the seventh membrane span and a Schiff-base counterion in the third membrane span. The primary sequence of P-opsin suggests that it will be maximally sensitive to ∼500-nanometer light and produce a slow and prolonged phototransduction response consistent with the nonvisual function of pineal photoreception. |
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| AbstractList | Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46 percent identical to that of the retinal opsins. P-opsin is a seven-membrane spanning, G protein-linked receptor with a Schiff-base lysine in the seventh membrane span and a Schiff-base counterion in the third membrane span. The primary sequence of P-opsin suggests that it will be maximally sensitive to ∼500-nanometer light and produce a slow and prolonged phototransduction response consistent with the nonvisual function of pineal photoreception. Pineal opsin, an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. The amino acid sequence of pineal opsin is 42-46% identical to that of the retinal opsins. Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46 percent identical to that of the retinal opsins. P-opsin is a seven-membrane spanning, G protein-linked receptor with a Schiff-base lysine in the seventh membrane span and a Schiff-base counterion in the third membrane span. The primary sequence of P-opsin suggests that it will be maximally sensitive to ~500-nanometer light and produce a slow and prolonged phototransduction response consistent with the nonvisual function of pineal photoreception. Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46 percent identical to that of the retinal opsins. P-opsin is a seven-membrane spanning, G protein-linked receptor with a Schiff-base lysine in the seventh membrane span and a Schiff-base counterion in the third membrane span. The primary sequence of P-opsin suggests that it will be maximally sensitive to similar to 500-nanometer light and produce a slow and prolonged phototransduction response consistent with the nonvisual function of pineal photoreception. Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46 percent identical to that of the retinal opsins. P-opsin is a seven-membrane spanning, G protein-linked receptor with a Schiff-base lysine in the seventh membrane span and a Schiff-base counterion in the third membrane span. The primary sequence of P-opsin suggests that it will be maximally sensitive to approximately 500-nanometer light and produce a slow and prolonged phototransduction response consistent with the nonvisual function of pineal photoreception. |
| Audience | Academic |
| Author | Margolskee, Robert F. Takahashi, Joseph S. McKinnon, Peter J. Applebury, Meredithe L. Barrett, R. Keith Seidenman, Kenneth J. Max, Marianna |
| Author_xml | – sequence: 1 givenname: Marianna surname: Max fullname: Max, Marianna – sequence: 2 givenname: Peter J. surname: McKinnon fullname: McKinnon, Peter J. – sequence: 3 givenname: Kenneth J. surname: Seidenman fullname: Seidenman, Kenneth J. – sequence: 4 givenname: R. Keith surname: Barrett fullname: Barrett, R. Keith – sequence: 5 givenname: Meredithe L. surname: Applebury fullname: Applebury, Meredithe L. – sequence: 6 givenname: Joseph S. surname: Takahashi fullname: Takahashi, Joseph S. – sequence: 7 givenname: Robert F. surname: Margolskee fullname: Margolskee, Robert F. |
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| ContentType | Journal Article |
| Copyright | Copyright 1995 American Association for the Advancement of Science 1995 INIST-CNRS COPYRIGHT 1995 American Association for the Advancement of Science COPYRIGHT 1995 American Association for the Advancement of Science Copyright American Association for the Advancement of Science Mar 10, 1995 |
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| Keywords | Vertebrata Endocrine gland Molecular structure Pigments Pineal body Opsin Chicken Aves Gene expression Aminoacid sequence |
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| Snippet | Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It... Pineal opsin, an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. The amino... |
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| SubjectTerms | Amino Acid Sequence Amino acids Animals Avian Proteins Base Sequence Biological and medical sciences Biological Evolution Brain Chemistry Cell culture techniques Chickens Cloning, Molecular Coding Complementary DNA Fundamental and applied biological sciences. Psychology Hypothalamus. Hypophysis. Epiphysis. Urophysis Introns Libraries Light Molecular Sequence Data Morphology. Functional localizations Nerve Tissue Proteins - analysis Nerve Tissue Proteins - chemistry Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Opsins Photoreceptors Physiological aspects Pineal gland Pineal Gland - chemistry Polymerase chain reaction Protein Structure, Secondary Proteins Retina Retina - chemistry RNA RNA, Messenger - analysis Rod Opsins - analysis Rod Opsins - chemistry Rod Opsins - genetics Rod Opsins - physiology Sequence Homology, Amino Acid Transcripts (Written Records) Vertebrates Vertebrates: endocrinology |
| Title | Pineal Opsin: A Nonvisual Opsin Expressed in Chick Pineal |
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