Effects of Statin Therapy on Clinical Outcomes of Survivors of Acute Myocardial Infarction with Severe Systolic Heart Failure
Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI). Between January 2008 and December...
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| Published in: | PloS one Vol. 10; no. 12; p. e0144602 |
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| Abstract | Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI).
Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multi-center, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction ≤ 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299). We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis.
In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79-1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75-2.70, p = 0.28).
Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study. |
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| AbstractList | Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI).
Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multi-center, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction ≤ 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299). We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis.
In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79-1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75-2.70, p = 0.28).
Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study. Objective Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI). Methods Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multi-center, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction [less than or equal to] 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299). We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis. Results In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79-1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75-2.70, p = 0.28). Conclusion Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study. Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI). Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multi-center, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction [less than or equal to] 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299). We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis. In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79-1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75-2.70, p = 0.28). Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study. OBJECTIVELarge randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI).METHODSBetween January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multi-center, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction ≤ 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299). We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis.RESULTSIn the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79-1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75-2.70, p = 0.28).CONCLUSIONStatin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study. Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI).Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multi-center, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction ≤ 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299). We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis.In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79-1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75-2.70, p = 0.28).Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study. Objective Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI). Methods Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multi-center, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction ≤ 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299). We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis. Results In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79–1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75–2.70, p = 0.28). Conclusion Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study. Objective Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of statin therapy in patients with new onset heart failure (HF) following acute myocardial infarction (AMI). Methods Between January 2008 and December 2011, a total of 13,616 AMI patients were enrolled in the Korea Acute Myocardial Infarction Registry (KAMIR) which was a prospective, multi-center, nationwide, web-based database of AMI in Korea. From this database, we studied 1,055 patients with AMI who had newly developed severe acute HF [left ventricular ejection fraction ≤ 40%] and were discharged alive. The patients were divided into two groups, a statin group (n = 756) and a no-statin group (n = 299). We investigated the one-year major adverse cardiovascular events (MACEs), including all-cause mortality, MI, and any revascularization of each group. We then performed a propensity-score matched analysis. Results In the original cohort, one-year MACEs were similar between the two groups (16.5% vs. 14.7% in the statin or no-statin groups; p = 0.47). Propensity-score matching yielded 256 pairs, and in that population we observed comparable results in terms of MACEs (18.0% vs. 12.5% in the statin or no-statin groups, p = 0.11) and mortality (5.1% vs. 3.5% in the statin or no-statin groups, p = 0.51). Cox-regression analysis revealed that statin therapy was not an independent predictor for occurrence of a MACE [Hazard ratio (HR) 1.11, 95% CI 0.79–1.57, p = 0.54] or all-cause mortality (HR 1.42, 95% CI 0.75–2.70, p = 0.28). Conclusion Statin therapy was not associated with a reduction in the long-term occurrence of MACEs or mortality in survivors of AMI with severe acute HF in this retrospective cohort study. |
| Audience | Academic |
| Author | Kim, Weon Kim, Woo-Shik Jeong, Myung Ho Kim, Hyun Soo Woo, Jong Shin Kim, Jin Bae Hwang, Seung Joon Kim, Kwon Sam |
| AuthorAffiliation | University of Manitoba, CANADA 1 Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea 2 Division of Cardiology, Department of Medicine, Chonnam National University Hospital, Gwangju, Korea |
| AuthorAffiliation_xml | – name: University of Manitoba, CANADA – name: 1 Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea – name: 2 Division of Cardiology, Department of Medicine, Chonnam National University Hospital, Gwangju, Korea |
| Author_xml | – sequence: 1 givenname: Jong Shin surname: Woo fullname: Woo, Jong Shin organization: Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea – sequence: 2 givenname: Seung Joon surname: Hwang fullname: Hwang, Seung Joon organization: Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea – sequence: 3 givenname: Hyun Soo surname: Kim fullname: Kim, Hyun Soo organization: Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea – sequence: 4 givenname: Jin Bae surname: Kim fullname: Kim, Jin Bae organization: Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea – sequence: 5 givenname: Woo-Shik surname: Kim fullname: Kim, Woo-Shik organization: Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea – sequence: 6 givenname: Kwon Sam surname: Kim fullname: Kim, Kwon Sam organization: Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea – sequence: 7 givenname: Myung Ho surname: Jeong fullname: Jeong, Myung Ho organization: Division of Cardiology, Department of Medicine, Chonnam National University Hospital, Gwangju, Korea – sequence: 8 givenname: Weon surname: Kim fullname: Kim, Weon organization: Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26658751$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_jjcc_2017_10_009 crossref_primary_10_1007_s10557_018_6769_y crossref_primary_10_3390_jcm11195643 |
| Cites_doi | 10.1016/S0140-6736(07)61602-X 10.1111/j.1751-7133.2010.00165.x 10.1056/NEJMoa050461 10.1136/bmj.g4356 10.1056/NEJMoa040583 10.1016/j.jacc.2008.07.044 10.1016/j.jacc.2010.02.075 10.1016/j.jacl.2013.10.001 10.1016/S0140-6736(08)61240-4 10.1016/j.ijcard.2006.03.057 10.3904/kjim.2014.29.6.703 10.1054/jcaf.2002.0804216 10.1016/j.amjcard.2004.01.039 10.1001/jama.296.17.2105 10.1016/j.jacc.2009.10.015 10.1016/j.ijcard.2006.07.106 10.1016/j.jacc.2003.07.016 10.1016/S0140-6736(00)02690-8 10.1093/eurjhf/hfs128 10.1016/j.jacc.2007.10.009 10.1056/NEJMoa0706201 10.1093/eurheartj/ehr158 10.1161/CIRCULATIONAHA.106.685313 |
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| DOI | 10.1371/journal.pone.0144602 |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceived and designed the experiments: JSW SJH MHJ WK. Performed the experiments: JSW SJH HSK JBK WSK KSK MHJ WK. Analyzed the data: JSW SJH WK. Contributed reagents/materials/analysis tools: JSW SJH HSK JBK WSK KSK MHJ WK. Wrote the paper: JSW SJH HSK JBK WSK KSK WK. Membership of the Korea Acute Myocardial Infarction Registry is provided in the Acknowledgments. Competing Interests: The authors have declared that no competing interests exist. |
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| References | 25035388 - BMJ. 2014;349:g4356 20883926 - J Am Coll Cardiol. 2010 Oct 5;56(15):1196-204 15110204 - Am J Cardiol. 2004 May 1;93(9):1124-9 19942100 - J Am Coll Cardiol. 2009 Dec 1;54(23):2205-41 14662255 - J Am Coll Cardiol. 2003 Dec 3;42(11):1933-40 18064739 - Lancet. 2007 Oct 20;370(9596):1453-7 17984166 - N Engl J Med. 2007 Nov 29;357(22):2248-61 18757089 - Lancet. 2008 Oct 4;372(9645):1231-9 16846656 - Int J Cardiol. 2006 Sep 20;112(2):234-42 15007110 - N Engl J Med. 2004 Apr 8;350(15):1495-504 17049646 - Int J Cardiol. 2007 Jun 25;119(1):48-53 19017509 - J Am Coll Cardiol. 2008 Oct 28;52(18):1435-41 25378967 - Korean J Intern Med. 2014 Nov;29(6):703-12 11036910 - Lancet. 2000 Sep 9;356(9233):930-3 15198965 - Circulation. 2004 Jun 15;109(23 Suppl 1):III39-43 15755765 - N Engl J Med. 2005 Apr 7;352(14):1425-35 22872593 - Eur J Heart Fail. 2013 Feb;15(2):221-7 24222016 - Circulation. 2014 Jun 24;129(25 Suppl 2):S1-45 21603349 - Ochsner J. 2010 Spring;10(1):16-21 20662872 - Congest Heart Fail. 2010 Jul-Aug;16(4):181-6 24314355 - J Clin Lipidol. 2013 Nov-Dec;7(6):561-5 17470709 - Circulation. 2007 May 1;115(17):2344-51 21712404 - Eur Heart J. 2011 Jul;32(14):1769-818 18222351 - J Am Coll Cardiol. 2008 Jan 29;51(4):415-26 17077375 - JAMA. 2006 Nov 1;296(17):2105-11 12397569 - J Card Fail. 2002 Aug;8(4):216-24 K Ramasubbu (ref16) 2008; 51 SL Molyneux (ref20) 2008; 52 CP Cannon (ref1) 2004; 350 JJ McMurray (ref22) 2010; 56 SM Grundy (ref25) 2013; 7 HK Kim (ref12) 2014; 29 D Mozaffarian (ref3) 2004; 93 R Sankaranarayanan (ref15) 2010; 16 J Kjekshus (ref7) 2007; 357 DE Cutlip (ref13) 2007; 115 Z Reiner (ref24) 2011; 32 L Tavazzi (ref8) 2008; 372 J Davignon (ref9) 2004; 109 D Dobre (ref14) 2013; 15 E von Elm (ref11) 2007; 370 S Rabar (ref26) 2014; 349 AS Go (ref5) 2006; 296 TB Horwich (ref17) 2002; 8 FG Kushner (ref10) 2009; 54 R Deichmann (ref21) 2010; 10 JC LaRosa (ref2) 2005; 352 NJ Stone (ref23) 2014; 129 H Krum (ref6) 2007; 119 M Rauchhaus (ref18) 2003; 42 M Rauchhaus (ref19) 2000; 356 SD Anker (ref4) 2006; 112 |
| References_xml | – volume: 129 issue: 25 year: 2014 ident: ref23 article-title: 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines publication-title: Circulation contributor: fullname: NJ Stone – volume: 370 start-page: 1453 issue: 9596 year: 2007 ident: ref11 article-title: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies publication-title: Lancet doi: 10.1016/S0140-6736(07)61602-X contributor: fullname: E von Elm – volume: 16 start-page: 181 issue: 4 year: 2010 ident: ref15 article-title: Do statins improve heart failure outcome in post-myocardial infarction patients with moderate to severe left ventricular dysfunction? publication-title: Congest Heart Fail doi: 10.1111/j.1751-7133.2010.00165.x contributor: fullname: R Sankaranarayanan – volume: 352 start-page: 1425 issue: 14 year: 2005 ident: ref2 article-title: Intensive lipid lowering with atorvastatin in patients with stable coronary disease publication-title: N Engl J Med doi: 10.1056/NEJMoa050461 contributor: fullname: JC LaRosa – volume: 349 start-page: g4356 year: 2014 ident: ref26 article-title: Lipid modification and cardiovascular risk assessment for the primary and secondary prevention of cardiovascular disease: summary of updated NICE guidance publication-title: BMJ doi: 10.1136/bmj.g4356 contributor: fullname: S Rabar – volume: 350 start-page: 1495 issue: 15 year: 2004 ident: ref1 article-title: Intensive versus moderate lipid lowering with statins after acute coronary syndromes publication-title: N Engl J Med doi: 10.1056/NEJMoa040583 contributor: fullname: CP Cannon – volume: 52 start-page: 1435 issue: 18 year: 2008 ident: ref20 article-title: Coenzyme Q10: an independent predictor of mortality in chronic heart failure publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2008.07.044 contributor: fullname: SL Molyneux – volume: 56 start-page: 1196 issue: 15 year: 2010 ident: ref22 article-title: Coenzyme Q10, rosuvastatin, and clinical outcomes in heart failure: a pre-specified substudy of CORONA (controlled rosuvastatin multinational study in heart failure) publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2010.02.075 contributor: fullname: JJ McMurray – volume: 7 start-page: 561 issue: 6 year: 2013 ident: ref25 article-title: An International Atherosclerosis Society Position Paper: global recommendations for the management of dyslipidemia publication-title: J Clin Lipidol doi: 10.1016/j.jacl.2013.10.001 contributor: fullname: SM Grundy – volume: 372 start-page: 1231 issue: 9645 year: 2008 ident: ref8 article-title: Effect of rosuvastatin in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial publication-title: Lancet doi: 10.1016/S0140-6736(08)61240-4 contributor: fullname: L Tavazzi – volume: 112 start-page: 234 issue: 2 year: 2006 ident: ref4 article-title: Statin use and survival in patients with chronic heart failure—results from two observational studies with 5200 patients publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2006.03.057 contributor: fullname: SD Anker – volume: 29 start-page: 703 issue: 6 year: 2014 ident: ref12 article-title: The scientific achievements of the decades in Korean Acute Myocardial Infarction Registry publication-title: Korean J Intern Med doi: 10.3904/kjim.2014.29.6.703 contributor: fullname: HK Kim – volume: 8 start-page: 216 issue: 4 year: 2002 ident: ref17 article-title: Low serum total cholesterol is associated with marked increase in mortality in advanced heart failure publication-title: J Card Fail doi: 10.1054/jcaf.2002.0804216 contributor: fullname: TB Horwich – volume: 93 start-page: 1124 issue: 9 year: 2004 ident: ref3 article-title: Statin therapy is associated with lower mortality among patients with severe heart failure publication-title: Am J Cardiol doi: 10.1016/j.amjcard.2004.01.039 contributor: fullname: D Mozaffarian – volume: 296 start-page: 2105 issue: 17 year: 2006 ident: ref5 article-title: Statin therapy and risks for death and hospitalization in chronic heart failure publication-title: JAMA doi: 10.1001/jama.296.17.2105 contributor: fullname: AS Go – volume: 54 start-page: 2205 issue: 23 year: 2009 ident: ref10 article-title: 2009 focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (updating the 2004 guideline and 2007 focused update) and ACC/AHA/SCAI guidelines on percutaneous coronary intervention (updating the 2005 guideline and 2007 focused update) a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2009.10.015 contributor: fullname: FG Kushner – volume: 119 start-page: 48 issue: 1 year: 2007 ident: ref6 article-title: Statins and symptomatic chronic systolic heart failure: a post-hoc analysis of 5010 patients enrolled in Val-HeFT publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2006.07.106 contributor: fullname: H Krum – volume: 42 start-page: 1933 issue: 11 year: 2003 ident: ref18 article-title: The relationship between cholesterol and survival in patients with chronic heart failure publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2003.07.016 contributor: fullname: M Rauchhaus – volume: 356 start-page: 930 issue: 9233 year: 2000 ident: ref19 article-title: The endotoxin-lipoprotein hypothesis publication-title: Lancet doi: 10.1016/S0140-6736(00)02690-8 contributor: fullname: M Rauchhaus – volume: 109 issue: 23 year: 2004 ident: ref9 article-title: Beneficial cardiovascular pleiotropic effects of statins publication-title: Circulation contributor: fullname: J Davignon – volume: 15 start-page: 221 issue: 2 year: 2013 ident: ref14 article-title: Statin therapy and clinical outcomes in myocardial infarction patients complicated by acute heart failure: insights from the EPHESUS trial publication-title: Eur J Heart Fail doi: 10.1093/eurjhf/hfs128 contributor: fullname: D Dobre – volume: 10 start-page: 16 issue: 1 year: 2010 ident: ref21 article-title: Coenzyme q10 and statin-induced mitochondrial dysfunction publication-title: Ochsner J contributor: fullname: R Deichmann – volume: 51 start-page: 415 issue: 4 year: 2008 ident: ref16 article-title: Experimental and clinical basis for the use of statins in patients with ischemic and nonischemic cardiomyopathy publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2007.10.009 contributor: fullname: K Ramasubbu – volume: 357 start-page: 2248 issue: 22 year: 2007 ident: ref7 article-title: Rosuvastatin in older patients with systolic heart failure publication-title: N Engl J Med doi: 10.1056/NEJMoa0706201 contributor: fullname: J Kjekshus – volume: 32 start-page: 1769 issue: 14 year: 2011 ident: ref24 article-title: ESC/EAS Guidelines for the management of dyslipidaemias: the Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) publication-title: Eur Heart J doi: 10.1093/eurheartj/ehr158 contributor: fullname: Z Reiner – volume: 115 start-page: 2344 issue: 17 year: 2007 ident: ref13 article-title: Clinical end points in coronary stent trials: a case for standardized definitions publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.106.685313 contributor: fullname: DE Cutlip |
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| Snippet | Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term effects of... Objective Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term... OBJECTIVELarge randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term... Objective Large randomized trials have failed to show a beneficial effect of statin treatment in chronic HF. The investigators tried to evaluate the long-term... |
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| Title | Effects of Statin Therapy on Clinical Outcomes of Survivors of Acute Myocardial Infarction with Severe Systolic Heart Failure |
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