Minimum information about a protein affinity reagent (MIAPAR)

• Published in: Nature biotechnology Vol. 28; no. 7; pp. 650 - 653
• Main Authors: Orchard, Sandra, Bourbeillon, Julie, Benhar, Itai, Borrebaeck, Carl, de Daruvar, Antoine, Dübel, Stefan, Frank, Ronald, Gibson, Frank, Gloriam, David, Haslam, Niall, Hiltker, Tara, Humphrey-Smith, Ian, Hust, Michael, Juncker, David, Koegl, Manfred, Konthur, Zoltàn, Korn, Bernhard, Krobitsch, Sylvia, Muyldermans, Serge, Nygren, Per-Åke, Palcy, Sandrine, Polic, Bojan, Rodriguez, Henry, Sawyer, Alan, Schlapshy, Martin, Snyder, Michael, Stoevesandt, Oda, Taussig, Michael J, Templin, Markus, Uhlen, Matthias, van der Maarel, Silvere, Wingren, Christer, Hermjakob, Henning, Sherman, David
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01-07-2010; Nature Publishing Group
• Subjects: 631/1647/2196; Affinity Labels; Agriculture; Basic Medicine; Biochemistry; Bioinformatics; Biomedical and Life Sciences; Biomedical Engineering/Biotechnology; Biomedicine; Biotechnology; Chemical tests and reagents; Computer Science; correspondence; Immunologi inom det medicinska området; Immunology in the medical area; Indicators and Reagents - chemistry; Life Sciences; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Methods; Product development; Properties; Proteins - chemistry; Proteomics; Quantitative Methods; Germany
• ISSN: 1087-0156; 1546-1696; 1546-1696
• DOI: 10.1038/nbt0710-650

This is a proposal developed within the community as an important first step in formalizing standards in reporting the production and properties of protein binding reagents, such as antibodies, developed and sold for the identification and detection of specific proteins present in biological samples. It defines a checklist of required information, intended for use by producers of affinity reagents, quality-control laboratories, users and databases. We envision that both commercial and freely available affinity reagents, as well as published studies using these reagents, could include a MIAPAR-compliant document describing the product's properties with every available binding partner.