PCR-Based Simple Subgrouping Is Validated for Classification of Gliomas and Defines Negative Prognostic Copy Number Aberrations in IDH Mutant Gliomas

Genetic subgrouping of gliomas has been emphasized recently, particularly after the finding of isocitrate dehydrogenase 1 (IDH1) mutations. In a previous study, we investigated whole-chromosome copy number aberrations (CNAs) of gliomas and have described genetic subgrouping based on CNAs and IDH1 mu...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 11; p. e0142750
Main Authors:	Nakae, Shunsuke, Sasaki, Hikaru, Hayashi, Saeko, Hattori, Natsuki, Kumon, Masanobu, Nishiyama, Yuya, Adachi, Kazuhide, Nagahisa, Shinya, Hayashi, Takuro, Inamasu, Joji, Abe, Masato, Hasegawa, Mitsuhiro, Hirose, Yuichi
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 11-11-2015 Public Library of Science (PLoS)
Subjects:	Adult Brain cancer Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - pathology Chromosome Aberrations Classification Copy number Copy number variations Deoxyribonucleic acid Development and progression Disease-Free Survival DNA DNA Mutational Analysis Exons Female Genetic aspects Genetic screening Genomes Glioma Glioma - genetics Glioma - mortality Glioma - pathology Gliomas Humans Identification and classification Isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Kaplan-Meier Estimate Male Markers Medical diagnosis Medical prognosis Methods Middle Aged Mutation Neoplasm Grading Neoplasm Recurrence, Local Neurosurgery p53 Protein Patients Polymerase Chain Reaction Prognosis Subgroups Survival Survival analysis Tumor Suppressor Protein p53 - genetics Tumors Japan
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