Deep brain stimulation of nucleus accumbens region in alcoholism affects reward processing

The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H(2)[(15)O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 5; p. e36572
Main Authors:	Heldmann, Marcus, Berding, Georg, Voges, Jürgen, Bogerts, Bernhard, Galazky, Imke, Müller, Ulf, Baillot, Gunther, Heinze, Hans-Jochen, Münte, Thomas F
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 22-05-2012 Public Library of Science (PLoS)
Subjects:	Addiction Addictions Adult Alcoholism Alcoholism - diagnostic imaging Alcoholism - physiopathology Alcoholism - therapy Alcohols Biology Brain Cortex (parietal) Cortex (temporal) Data analysis Data processing Deactivation Decision making Deep Brain Stimulation Drug abuse Drug addiction Electrodes Emission analysis Feasibility studies Gambling Humans Information management Male Medical imaging Medicine Neurology Neuropsychological Tests Nuclear medicine Nuclei Nucleus accumbens Nucleus Accumbens - diagnostic imaging Nucleus Accumbens - physiopathology Positron emission Positron emission tomography Radionuclide Imaging Reinforcement Review boards Reward Risk-Taking Rodents Stimulation Tomography Germany
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Summary:	The influence of bilateral deep brain stimulation (DBS) of the nucleus nucleus (NAcc) on the processing of reward in a gambling paradigm was investigated using H(2)[(15)O]-PET (positron emission tomography) in a 38-year-old man treated for severe alcohol addiction. Behavioral data analysis revealed a less risky, more careful choice behavior under active DBS compared to DBS switched off. PET showed win- and loss-related activations in the paracingulate cortex, temporal poles, precuneus and hippocampus under active DBS, brain areas that have been implicated in action monitoring and behavioral control. Except for the temporal pole these activations were not seen when DBS was deactivated. These findings suggest that DBS of the NAcc may act partially by improving behavioral control.
Bibliography:	Conceived and designed the experiments: TFM MH. Performed the experiments: MH G. Berding G. Baillot. Analyzed the data: MH G. Berding. Wrote the paper: TFM MH JV HJH G. Berding.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0036572