Virulence evolution of the human pathogen Neisseria meningitidis by recombination in the core and accessory genome

Neisseria meningitidis is a naturally transformable, facultative pathogen colonizing the human nasopharynx. Here, we analyze on a genome-wide level the impact of recombination on gene-complement diversity and virulence evolution in N. meningitidis. We combined comparative genome hybridization using...

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Bibliographic Details
Published in:	PloS one Vol. 6; no. 4; p. e18441
Main Authors:	Joseph, Biju, Schwarz, Roland F, Linke, Burkhard, Blom, Jochen, Becker, Anke, Claus, Heike, Goesmann, Alexander, Frosch, Matthias, Müller, Tobias, Vogel, Ulrich, Schoen, Christoph
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 26-04-2011 Public Library of Science (PLoS)
Subjects:	Analysis Bioinformatics Biology Biotechnology Cluster Analysis Comparative Genomic Hybridization Computer applications Deoxyribonucleic acid Differential distribution DNA DNA biosynthesis DNA microarrays DNA repair DNA replication Epidemics Evolution Evolution, Molecular Evolutionary biology Gene Pool Gene sequencing Gene transfer Genes Genetic research Genome, Bacterial - genetics Genomes Genomic islands Genomics Health care Homologous recombination Homology Humans Hybridization Hygiene Laboratories Medical research Meningitis Meningococcal disease Metabolism Multilocus Sequence Typing Mutation Nasopharynx Neisseria Neisseria meningitidis Neisseria meningitidis - classification Neisseria meningitidis - genetics Neisseria meningitidis - pathogenicity Nucleotide sequence Pathogens Phylogenetics Phylogeny Physiological aspects Population Population structure Prophages Proteins Recombination, Genetic - genetics Secretion Serotyping Studies Vaccines Virulence Virulence (Microbiology) Virulence - genetics Germany
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