Hydroxylated Analogues of ATP-Sensitive Potassium Channel Openers Belonging to the Group of 6- and/or 7-Substituted 3-Isopropylamino-4 H -1,2,4-benzothiadiazine 1,1-Dioxides: Toward an Improvement in Sulfonylurea Receptor 1 Selectivity and Metabolism Stability
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Published in: | Journal of medicinal chemistry Vol. 54; no. 24; pp. 8353 - 8361 |
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Main Authors: | , , , , , , , |
Format: | Journal Article |
Language: | English |
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22-12-2011
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Author | Chiap, Patrice Servais, Anne-Catherine Somers, Fabian de Tullio, Pascal Fillet, Marianne Pirotte, Bernard Gillotin, Florian Lebrun, Philippe |
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Author_xml | – sequence: 1 givenname: Pascal surname: de Tullio fullname: de Tullio, Pascal organization: Drug Research Center, Laboratoire de Chimie Pharmaceutique, Université de Liège, 1 Avenue de l’Hôpital, B36, 4000 Liège, Belgium – sequence: 2 givenname: Anne-Catherine surname: Servais fullname: Servais, Anne-Catherine organization: Drug Research Center, Laboratoire d’Analyse des Médicaments, Université de Liège, 1 Avenue de l’Hôpital, B36, 4000 Liège, Belgium – sequence: 3 givenname: Marianne surname: Fillet fullname: Fillet, Marianne organization: Drug Research Center, Laboratoire d’Analyse des Médicaments, Université de Liège, 1 Avenue de l’Hôpital, B36, 4000 Liège, Belgium – sequence: 4 givenname: Florian surname: Gillotin fullname: Gillotin, Florian organization: Advanced Technology Corporation (ATC s.a.), Centre Hospitalier Universitaire de Liège (CHU), 1 Avenue de l’Hôpital, 4000 Liège, Belgium – sequence: 5 givenname: Fabian surname: Somers fullname: Somers, Fabian organization: Drug Research Center, Laboratoire de Chimie Pharmaceutique, Université de Liège, 1 Avenue de l’Hôpital, B36, 4000 Liège, Belgium – sequence: 6 givenname: Patrice surname: Chiap fullname: Chiap, Patrice organization: Advanced Technology Corporation (ATC s.a.), Centre Hospitalier Universitaire de Liège (CHU), 1 Avenue de l’Hôpital, 4000 Liège, Belgium – sequence: 7 givenname: Philippe surname: Lebrun fullname: Lebrun, Philippe organization: Laboratoire de Pharmacodynamie et de Thérapeutique, Université Libre de Bruxelles, 808 route de Lennik, 1070 Bruxelles, Belgium – sequence: 8 givenname: Bernard surname: Pirotte fullname: Pirotte, Bernard organization: Drug Research Center, Laboratoire de Chimie Pharmaceutique, Université de Liège, 1 Avenue de l’Hôpital, B36, 4000 Liège, Belgium |
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Cites_doi | 10.1126/science.270.5239.1166 10.1016/j.yjmcc.2004.12.003 10.1007/978-1-4899-1819-2_19 10.1055/s-2007-978639 10.1021/jm060534w 10.1007/s001250051370 10.1146/annurev.physiol.60.1.667 10.1016/j.bcp.2007.08.032 10.1124/dmd.109.028928 10.1016/j.bbabio.2006.05.002 10.1021/jm0311339 10.1242/jeb.01106 10.1016/0163-7258(96)00003-4 10.1021/jm0580050 10.1021/jm9010093 10.1021/jm021117w 10.1677/jme.0.0220113 10.1016/j.yjmcc.2004.11.024 10.1161/01.RES.0000186277.12336.11 10.2174/092986706775527947 10.1146/annurev.physiol.61.1.337 10.1016/j.bcp.2008.09.004 10.1540/jsmr.44.65 |
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Title | Hydroxylated Analogues of ATP-Sensitive Potassium Channel Openers Belonging to the Group of 6- and/or 7-Substituted 3-Isopropylamino-4 H -1,2,4-benzothiadiazine 1,1-Dioxides: Toward an Improvement in Sulfonylurea Receptor 1 Selectivity and Metabolism Stability |
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