Deacetylation of phosphoglycerate mutase in its distinct central region by SIRT 2 down‐regulates its enzymatic activity

Substantially high rate of glycolysis, known as the Warburg effect, is a well‐known feature of cancers, and emerging evidence suggests that it supports cancerous proliferation/tumor growth. Phosphoglycerate mutase ( PGAM ), a glycolytic enzyme, is commonly up‐regulated in several cancers, and recent...

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Bibliographic Details

Published in:	Genes to cells : devoted to molecular & cellular mechanisms Vol. 19; no. 10; pp. 766 - 777
Main Authors:	Tsusaka, Takeshi, Guo, Tingting, Yagura, Teiti, Inoue, Toshiaki, Yokode, Masayuki, Inagaki, Nobuya, Kondoh, Hiroshi
Format:	Journal Article
Language:	English
Published:	01-10-2014
Online Access:	Get full text
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