Adipokines demonstrate the interacting influence of central obesity with other cardiometabolic risk factors of metabolic syndrome in Hong Kong Chinese adults

• Published in: PloS one Vol. 13; no. 8; p. e0201585
• Main Authors: Supriya, Rashmi, Tam, Bjorn T, Yu, Angus P, Lee, Paul H, Lai, Christopher W, Cheng, Kenneth K, Yau, Sonata Y, Chan, Lawrence W, Yung, Benjamin Y, Sheridan, Sinead, Siu, Parco M
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16-08-2018; Public Library of Science (PLoS)
• Subjects: Abdomen; Adipokines - blood; Adiponectin; Adiponectin - blood; Adults; Aged; Analysis; Asian people; Atherosclerosis; Biological markers; Biology and Life Sciences; Biomarkers; Blood pressure; Cardiovascular disease; Cardiovascular Diseases; Cholesterol; Clustering; Cytokines; Diabetes; Diabetes mellitus; Dyslipidemia; Epidemics; Female; Gene expression; Health aspects; Health risk assessment; Health risks; High density lipoprotein; Hong Kong; Humans; Hyperglycemia; Hypertension; Hypertriglyceridemia; Inflammation; Informatics; Insulin; Insulin - blood; Insulin resistance; Interleukin; Interleukin 10; Interleukin 6; Interleukin 8; Internet; Leptin; Leptin - blood; Male; Medicine and Health Sciences; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - etiology; Metabolic Syndrome - metabolism; Metabolic syndrome X; Middle Aged; Morbidity; Obesity; Obesity, Abdominal - blood; Obesity, Abdominal - complications; Obesity, Abdominal - metabolism; Plasminogen activator inhibitors; Population studies; Public health; Resistance factors; Risk analysis; Risk Factors; Social sciences; Trends; Tumor Necrosis Factor-alpha - blood; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Tumors; Hong Kong; Hong Kong China; China
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0201585

Metabolic syndrome (MetS) or prediabetes is a complex disorder that is defined by a clustering of cardiometabolic risk factors, including obesity, hypertriglyceridemia, reduced high-density lipoprotein (HDL) cholesterol, hypertension, and insulin resistance. Among cardiometabolic risk factors, central obesity plays a key role in the development of MetS through alterations in the secretion of adipokines and interacts with other MetS risk factors to unfavorably influence overall cardiometabolic risk. Obesity has grasped epidemic proportions in Asia, which has the highest number of people with diabetes in the world. But, the importance of central obesity in the clustering of all four MetS risk factors or vice versa in predicting severity of MetS has not yet been investigated in Asian population. Therefore, the present study examined the influence of central obesity on circulating levels of adipokines through its interaction with the clustering of cardiometabolic risk factors of MetS including hyperglycemia, hypertriglyceridemia, dyslipidemia and hypertension in Hong Kong Chinese adults.
Blood samples from 83 Hong Kong Chinese adults, who were previously screened for MetS according to the guideline of the United States National Cholesterol Education Program Expert Panel Adult Treatment Panel III criteria were selected. Insulin and adipokines, including visfatin, chemerin, plasminogen activator inhibitor-1 (PAI-1), resistin, C-C motif chemokine ligand 2 (CCL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumour necrosis factor-α (TNF-α), leptin and adiponectin were assessed.
The interacting effect of central obesity with all of the other four MetS risk factors increased the proinflammatory status of adipokines (TNF-α, leptin) and decreased the anti-inflammatory status of adipokine (adiponectin).
Our results indicate that the inflammatory status of MetS may be more severe in the presence of central obesity. Adipokines, as biomarkers for pathophysiological changes, may help to improve early patient identification and to predict MetS-associated morbidity and mortality.