eHSP 70/ iHSP 70 and divergent functions on the challenge: effect of exercise and tissue specificity in response to stress

• Published in: Clinical physiology and functional imaging Vol. 37; no. 2; pp. 99 - 105
• Main Authors: Bittencourt, Aline, Porto, Rossana Rosa
• Format: Journal Article
• Language: English
• Published: 01-03-2017
• ISSN: 1475-0961; 1475-097X
• DOI: 10.1111/cpf.12273

Heat‐shock proteins including
HSP
70 are stress‐related proteins that have been reported in cell protection and survival. In contrast to this, the increase in circulating levels of
HSP
70 (
eHSP
70) is associated with cellular damage and inflammatory factors. Physical stress, like exercise, is effective to induce both
iHSP
70 and
eHSP
70 in several tissues and cell types, which have different behaviours in response to stress. The different functions of
HSP
70 before the challenge are dependent of intracellular localization and subsequent molecular chaperone action, but when present in the extracellular space, it activates pro‐inflammatory pathways. The different forms in which tissues and cells respond to stress like physical exercise, as well as the optimal intensity of the stress, are determinants for the beneficial effects or as an indicator of dangerous conditions, summoning immune cells as a warning sign to the body.