Short-Term and Long-Term FK506 Treatment Alters the Vascular Reactivity of Renal and Mesenteric Vascular Beds

The aims of this study were to investigate the role of endothelin-1 in FK506-induced hypertension and vascular dysfunction of rats treated with the drug for 8 (short-term) or 30 (long-term) days and to measure malondialdehyde levels in the kidneys. Kidney and mesentery of rats were perfused. In the...

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Bibliographic Details
Published in:	Journal of Pharmacological Sciences Vol. 102; no. 4; pp. 359 - 367
Main Authors:	Soydan, Guray, Tekes, Ender, Tuncer, Meral
Format:	Journal Article
Language:	English
Published:	Japan Elsevier B.V 2006 The Japanese Pharmacological Society Elsevier
Subjects:	Animals Antihypertensive Agents - pharmacology Blood Pressure - drug effects Bosentan Dose-Response Relationship, Drug Endothelin A Receptor Antagonists endothelin-1 Endothelin-1 - metabolism Hypertension - chemically induced Hypertension - metabolism Hypertension - physiopathology Immunosuppressive Agents - adverse effects Immunosuppressive Agents - blood isolated perfused kidney and mesentery Kidney - blood supply Kidney - metabolism Male malondialdehyde Malondialdehyde - metabolism Mesentery - blood supply Nitroprusside - pharmacology Norepinephrine - pharmacology Oxidative Stress - drug effects Rats Rats, Wistar Receptor, Endothelin A - metabolism Sulfonamides - pharmacology tacrolimus (FK506) Tacrolimus - adverse effects Tacrolimus - blood Time Factors Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Vasodilator Agents - pharmacology tacrolimus (FK506) malondialdehyde isolated perfused kidney and mesentery endothelin-1 bosentan
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