First screening of A edes albopictus immunogenic salivary proteins

• Published in: Insect molecular biology Vol. 22; no. 4; pp. 411 - 423
• Main Authors: Doucoure, S., Cornelie, S., Patramool, S., Mouchet, F., Demettre, E., Seveno, M., Dehecq, J. S., Rutee, H., Herve, J. P., Favier, F., Missé, D., Gasque, P., Remoue, F.
• Format: Journal Article
• Language: English
• Published: 01-08-2013
• ISSN: 0962-1075; 1365-2583
• DOI: 10.1111/imb.12032

Abstract
Study of the human antibody (
A
b) response to
A
edes
salivary proteins can provide new biomarkers to evaluate human exposure to vector bites. The identification of genus‐ and/or species‐specific proteins is necessary to improve the accuracy of biomarkers. We analysed
Aedes albopictus
immunogenic salivary proteins by 2D immunoproteomic technology and compared the profiles according to human individual exposure to
Ae. albopictus
or
Ae. aegypti
bites. Strong antigenicity to
A
e. albopictus
salivary proteins was detected in all individuals whatever the nature of
A
edes
exposure. Amongst these antigenic proteins, 68% are involved in blood feeding, including D7 protein family, adenosine deaminase, serpin and apyrase. This study provides an insight into the repertoire of
Ae. albopictus
immunogenic salivary proteins for the first time.