Combined Effects of Benidipine and Diltiazem in a Rat Model of Experimental Angina

• Published in: Journal of Pharmacological Sciences Vol. 95; no. 3; pp. 394 - 397
• Main Authors: Yao, Kozo, Shirakura, Shiro
• Format: Journal Article
• Language: English
• Published: Japan Elsevier B.V 2004; The Japanese Pharmacological Society; Elsevier
• Subjects: angina; Angina Pectoris - chemically induced; Angina Pectoris - drug therapy; Animals; Arginine Vasopressin; benidipine; Calcium Channel Blockers - administration & dosage; Calcium Channel Blockers - pharmacology; Calcium Channel Blockers - therapeutic use; Dihydropyridines - administration & dosage; Dihydropyridines - pharmacology; Dihydropyridines - therapeutic use; diltiazem; Diltiazem - administration & dosage; Diltiazem - pharmacology; Diltiazem - therapeutic use; Dose-Response Relationship, Drug; Drug Therapy, Combination; Electrocardiography; Male; Rats; Rats, Inbred Strains; Time Factors; Vasoconstrictor Agents; diltiazem; angina; benidipine
• ISSN: 1347-8613; 1347-8648
• DOI: 10.1254/jphs.SC0030119

We examined the combined effects of the calcium channel blockers 1,4-dihydropyridine (benidipine) and benzothiazepine (diltiazem) on vasopressin-induced myocardial ischemia in anesthetized rats, an experimental model of angina. Benidipine (3, 10 μg/kg, i.v.) and diltiazem (300, 1000 μg/kg, i.v.) caused dose-related inhibition of vasopressin-induced S-wave depression, an index of myocardial ischemia. Co-administration of low doses of benidipine (3 μg/kg) and diltiazem (300 μg/kg) almost completely inhibited the S-wave depression, where the efficacy was similar to that obtained with the use of high doses of benidipine (10 μg/kg) or diltiazem (1000 μg/kg). These results suggest that the administration strategy employed may be useful in the treatment of angina pectoris.