Alleviation of Ischemia-Induced Brain Edema by Activation of the Central Histaminergic System in Rats

We have reported that facilitation of central histaminergic activity prevents the development of ischemia-induced brain injury. Since cerebral edema is a major cause of brain damage, we studied effects on brain edema of postischemic administration of l-histidine, a precursor of histamine, and thiope...

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Bibliographic Details
Published in:	Journal of Pharmacological Sciences Vol. 108; no. 1; pp. 112 - 123
Main Authors:	Irisawa, Yumi, Adachi, Naoto, Liu, Keyue, Arai, Tatsuru, Nagaro, Takumi
Format:	Journal Article
Language:	English
Published:	Japan Elsevier B.V 2008 The Japanese Pharmacological Society Elsevier
Subjects:	Animals Blood Cell Count Body Water - drug effects Body Water - metabolism Brain Chemistry - drug effects brain edema Brain Edema - drug therapy Brain Edema - etiology Brain Edema - pathology Brain Ischemia - complications Brain Ischemia - drug therapy Brain Ischemia - pathology Cerebral Cortex - pathology cerebral ischemia Cytokines - biosynthesis histamine Histamine - physiology Histamine Agonists - therapeutic use Histamine Antagonists - therapeutic use Histidine - therapeutic use Infarction, Middle Cerebral Artery - pathology Infarction, Middle Cerebral Artery - prevention & control Male Malondialdehyde - metabolism Microdialysis middle cerebral artery Neostriatum - pathology Piperidines - therapeutic use Rats Rats, Wistar Superoxide Dismutase - metabolism thioperamide brain edema histamine thioperamide cerebral ischemia middle cerebral artery
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