Population pharmacokinetics of artesunate and dihydroartemisinin following intra-rectal dosing of artesunate in malaria patients

Intra-rectal artesunate has been developed as a potentially life-saving treatment of severe malaria in rural village settings where administration of parenteral antimalarial drugs is not possible. We studied the population pharmacokinetics of intra-rectal artesunate and the relationship with parasit...

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Published in:	PLoS medicine Vol. 3; no. 11; p. e444
Main Authors:	Simpson, Julie A, Agbenyega, Tsiri, Barnes, Karen I, Di Perri, Gianni, Folb, Peter, Gomes, Melba, Krishna, Sanjeev, Krudsood, Srivicha, Looareesuwan, Sornchai, Mansor, Sharif, McIlleron, Helen, Miller, Raymond, Molyneux, Malcolm, Mwenechanya, James, Navaratnam, Visweswaran, Nosten, Francois, Olliaro, Piero, Pang, Lorrin, Ribeiro, Isabela, Tembo, Madalitso, van Vugt, Michele, Ward, Steve, Weerasuriya, Kris, Win, Kyaw, White, Nicholas J
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-11-2006 Public Library of Science (PLoS)
Subjects:	Administration, Rectal Adolescent Adult Africa Aging - metabolism Analysis Antimalarials Antimalarials - administration & dosage Antimalarials - adverse effects Antimalarials - pharmacokinetics Antimalarials - therapeutic use Antiparasitic agents Artemisinins - administration & dosage Artemisinins - adverse effects Artemisinins - pharmacokinetics Artemisinins - therapeutic use Asia, Southeastern Care and treatment Child Child, Preschool Demography Drug dosages Drugs and adverse drug reactions Female Gender Humans Infant Infectious Diseases Malaria Malaria - drug therapy Male Medicine in Developing Countries Middle Aged Parasitemia - drug therapy Parasitemia - virology Parasites Parasitic diseases Patients Pharmacokinetics Pharmacology/Drug Discovery Researchers Salvage Therapy Sesquiterpenes - administration & dosage Sesquiterpenes - adverse effects Sesquiterpenes - pharmacokinetics Sesquiterpenes - therapeutic use Sex Factors Suppositories Treatment Outcome Asia, Southeastern Africa Southeast Asia Demography Suppositories Malaria Humans Middle Aged Africa Salvage Therapy Antimalarials Child, Preschool Administration, Rectal Infant Male Treatment Outcome Asia, Southeastern Artemisinins Sesquiterpenes Adolescent Sex Factors Aging Adult Female Parasitemia Child
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