Aquaporins and Ion Conductance

• Published in: Science (American Association for the Advancement of Science) Vol. 275; no. 5305; pp. 1490 - 1492
• Main Authors: Agre, Peter, Lee, M. Douglas, Devidas, Sreenivas, Guggino, William B., Sasaki, Sei, Uchida, Shinichi, Kuwahara, Michio, Fushimi, Kiyohide, Marumo, Fumiaki, Verkman, A. S., Yang, Baoxue, Deen, P. M. T., Mulders, S. M., Kansen, S. M., van Os, C. H., Fischbarg, Jorge, Kuang, Kunyan, Li, Jun, Iserovich, Pavel, Wen, Qian, Patil, Rajkumar V., Han, Zhiquang, Wax, Martin B., Regan, John W., Stamer, W. Daniel, Yool, Andrea J.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 07-03-1997; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Animals; Aquaporin 1; Aquaporin 5; Aquaporins; Aquatic life; Biological and medical sciences; Biological Transport - drug effects; Cations - metabolism; Cell Membrane - metabolism; Cell membranes. Ionic channels. Membrane pores; Cell structures and functions; Colforsin - pharmacology; Complementary RNA; Electric potential; Erythrocytes; Fundamental and applied biological sciences. Psychology; Ion Channels - genetics; Ion Channels - physiology; Ion exchange membranes; Ion Transport - drug effects; Ion-permeable membranes; Ions; Laboratories; Membrane potential; Membrane Proteins; Membranes (Biology); Molecular and cellular biology; Oocytes; P branes; Patch-Clamp Techniques; Ribonucleic acid; RNA; RNA, Complementary; Technical Comments; Water; Water - metabolism; Xenopus; Water; Vertebrata; Xenopus laevis; Amphibia; Ion transport; Salientia; Ionic conductance; Aquaporin
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.275.5305.1490

A study of membrane conductance in Xenopus Laevis oocytes injected with aquaporin1 (AQP1) complementary RNA observed ion conductance in the AQPI protein. However, several labs have not been able to reproduce the results.