Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria
Endothelial nitric oxide synthase (eNOS) deficiency exacerbates proteinuria and renal injury in several glomerular diseases, but the underlying mechanism is not fully understood. We recently showed that heparanase is essential for the development of experimental diabetic nephropathy and glomerulonep...
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| Published in: | PloS one Vol. 11; no. 8; p. e0160894 |
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| Abstract | Endothelial nitric oxide synthase (eNOS) deficiency exacerbates proteinuria and renal injury in several glomerular diseases, but the underlying mechanism is not fully understood. We recently showed that heparanase is essential for the development of experimental diabetic nephropathy and glomerulonephritis, and hypothesize that heparanase expression is regulated by eNOS. Here, we demonstrate that induction of adriamycin nephropathy (AN) in C57BL/6 eNOS-deficient mice leads to an increased glomerular heparanase expression accompanied with overt proteinuria, which was not observed in the AN-resistant wild type counterpart. In vitro, the eNOS inhibitor asymmetric dimethylarginine (ADMA) induced heparanase expression in cultured mouse glomerular endothelial cells. Moreover, ADMA enhanced transendothelial albumin passage in a heparanase-dependent manner. We conclude that eNOS prevents heparanase induction and the development of proteinuria. |
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| AbstractList | Endothelial nitric oxide synthase (eNOS) deficiency exacerbates proteinuria and renal injury in several glomerular diseases, but the underlying mechanism is not fully understood. We recently showed that heparanase is essential for the development of experimental diabetic nephropathy and glomerulonephritis, and hypothesize that heparanase expression is regulated by eNOS. Here, we demonstrate that induction of adriamycin nephropathy (AN) in C57BL/6 eNOS-deficient mice leads to an increased glomerular heparanase expression accompanied with overt proteinuria, which was not observed in the AN-resistant wild type counterpart. In vitro, the eNOS inhibitor asymmetric dimethylarginine (ADMA) induced heparanase expression in cultured mouse glomerular endothelial cells. Moreover, ADMA enhanced transendothelial albumin passage in a heparanase-dependent manner. We conclude that eNOS prevents heparanase induction and the development of proteinuria. Endothelial nitric oxide synthase (eNOS) deficiency exacerbates proteinuria and renal injury in several glomerular diseases, but the underlying mechanism is not fully understood. We recently showed that heparanase is essential for the development of experimental diabetic nephropathy and glomerulonephritis, and hypothesize that heparanase expression is regulated by eNOS. Here, we demonstrate that induction of adriamycin nephropathy (AN) in C57BL/6 eNOS-deficient mice leads to an increased glomerular heparanase expression accompanied with overt proteinuria, which was not observed in the AN-resistant wild type counterpart. In vitro , the eNOS inhibitor asymmetric dimethylarginine (ADMA) induced heparanase expression in cultured mouse glomerular endothelial cells. Moreover, ADMA enhanced transendothelial albumin passage in a heparanase-dependent manner. We conclude that eNOS prevents heparanase induction and the development of proteinuria. |
| Audience | Academic |
| Author | van Beneden, Katrien Garsen, Marjolein van der Vlag, Johan Berden, Jo Hm Li, Jinhua van den Branden, Christiane Rabelink, Ton J Rops, Angelique L |
| AuthorAffiliation | Temple University, UNITED STATES 3 Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels, Belgium 4 Department of Nephrology, Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands 2 Department of Anatomy and developmental Biology, Monash University, Clayton, Victoria, Australia 1 Department of Nephrology, Radboud university medical center, Nijmegen, The Netherlands |
| AuthorAffiliation_xml | – name: Temple University, UNITED STATES – name: 1 Department of Nephrology, Radboud university medical center, Nijmegen, The Netherlands – name: 3 Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels, Belgium – name: 4 Department of Nephrology, Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands – name: 2 Department of Anatomy and developmental Biology, Monash University, Clayton, Victoria, Australia |
| Author_xml | – sequence: 1 givenname: Marjolein surname: Garsen fullname: Garsen, Marjolein organization: Department of Nephrology, Radboud university medical center, Nijmegen, The Netherlands – sequence: 2 givenname: Angelique L surname: Rops fullname: Rops, Angelique L organization: Department of Nephrology, Radboud university medical center, Nijmegen, The Netherlands – sequence: 3 givenname: Jinhua surname: Li fullname: Li, Jinhua organization: Department of Anatomy and developmental Biology, Monash University, Clayton, Victoria, Australia – sequence: 4 givenname: Katrien surname: van Beneden fullname: van Beneden, Katrien organization: Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels, Belgium – sequence: 5 givenname: Christiane surname: van den Branden fullname: van den Branden, Christiane organization: Department of Human Anatomy, Liver Cell Biology Lab, Vrije Universiteit Brussel, Brussels, Belgium – sequence: 6 givenname: Jo Hm surname: Berden fullname: Berden, Jo Hm organization: Department of Nephrology, Radboud university medical center, Nijmegen, The Netherlands – sequence: 7 givenname: Ton J surname: Rabelink fullname: Rabelink, Ton J organization: Department of Nephrology, Einthoven Laboratory for Vascular Medicine, Leiden University Medical Center, Leiden, The Netherlands – sequence: 8 givenname: Johan orcidid: 0000-0001-7843-5918 surname: van der Vlag fullname: van der Vlag, Johan organization: Department of Nephrology, Radboud university medical center, Nijmegen, The Netherlands |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27505185$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2016 Public Library of Science 2016 Garsen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2016 Garsen et al 2016 Garsen et al |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: MG JHMB TJR JvdV.Performed the experiments: MG ALR.Analyzed the data: MG ALR.Contributed reagents/materials/analysis tools: JL KvB CvdB.Wrote the paper: MG ALR JL KvB CvdB JHMB TJR JvdV. |
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| Title | Endothelial Nitric Oxide Synthase Prevents Heparanase Induction and the Development of Proteinuria |
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