Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells

Visceral leishmaniasis (VL) is a disease caused by Leishmania infantum, which is transmitted by phlebotomine sandflies. Dogs are the main urban reservoir of this parasite and the disease presents similar characteristics in both humans and dogs. In this paper, we investigated the potential pathways i...

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Bibliographic Details
Published in:	PloS one Vol. 11; no. 5; p. e0156733
Main Authors:	Silva-O'Hare, Joselli, de Oliveira, Isabela Silva, Klevorn, Thaís, Almeida, Valter A, Oliveira, Geraldo G S, Atta, Ajax M, de Freitas, Luiz Antonio R, Dos-Santos, Washington L C
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 31-05-2016 Public Library of Science (PLoS)
Subjects:	Animals Antibodies, Protozoan - blood Antibodies, Protozoan - immunology Antigens APRIL protein B-Cell Activating Factor - biosynthesis Biology and Life Sciences BLyS protein Bone marrow Cell activation Cell migration Cell survival Chemokine CXCL12 - biosynthesis Chemokines CXCL12 protein Cytokines Development and progression Dog diseases Dog Diseases - parasitology Dogs Dysproteinemia Globulins Growth Homing Hypergammaglobulinemia Hypergammaglobulinemia - immunology Immunoglobulin A Immunoglobulin A - blood Immunoglobulin A - immunology Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulin M Immunoglobulin M - blood Immunoglobulin M - immunology Infections Isotypes Leishmania Leishmania infantum Leishmania infantum - genetics Leishmania infantum - immunology Leishmaniasis Leishmaniasis, Visceral - parasitology Leishmaniasis, Visceral - pathology Lupus Lymphocyte Activation - immunology Lymphocytes B Lymphoid tissue Lymphoid Tissue - cytology Lymphoid Tissue - immunology Lymphoid Tissue - parasitology Medicine and Health Sciences Parasitic diseases Pathogens Physiological aspects Plasma Plasma cells Plasma Cells - immunology Plasmacytosis Polymerase chain reaction Pulp Red pulp Research and Analysis Methods Serum Albumin - analysis Spleen Spleen - cytology Spleen - immunology Spleen - parasitology Surveillance Survival T cell receptors Tumor Necrosis Factor Ligand Superfamily Member 13 - biosynthesis Vector-borne diseases Visceral leishmaniasis Brazil
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