Mechanisms of regulatory diversity within the p53 transcriptional network

p53 is arguably the most intensively studied protein to date, yet there is much that we ignore about its function as a transcription factor. The p53-dependent transcriptional program is remarkably flexible, as it varies with the nature of p53-activating stimuli, the cell type and the duration of the...

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Bibliographic Details
Published in:	Oncogene Vol. 27; no. 29; pp. 4013 - 4023
Main Author:	Espinosa, J M
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 03-07-2008 Nature Publishing Nature Publishing Group
Subjects:	Animals Apoptosis Apoptosis - physiology Biological and medical sciences Cancer Cell activation Cell Biology Cell cycle Cell Cycle - physiology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Fundamental and applied biological sciences. Psychology Genetic aspects Genetic regulation Genetic transcription Genetics Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Models, Biological Molecular and cellular biology Molecular genetics Oncology p53 Protein Physiological aspects Proteins review Transcription, Genetic - physiology Transcription. Transcription factor. Splicing. Rna processing Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism United States lysine 120 ASPP HZF hCAS serine 46 p21 Transcription Serine CDKN1A Gene Carcinogenesis Mechanism TP53 Gene Lysine Tumor suppressor gene
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