Real-World Treatment Patterns and Vision Outcomes with Ranibizumab for Diabetic Macular Edema

• Published in: Journal of ophthalmology Vol. 2021; pp. 8825082 - 7
• Main Authors: Naujokaitis, Tadas, Balciuniene, Vilma Jurate
• Format: Journal Article
• Language: English
• Published: United States Hindawi 2021; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Care and treatment; Cataracts; Clinical medicine; Clinical trials; Diabetes; Diabetic retinopathy; Dropsy; Edema; Health sciences; Immunotherapy; Monoclonal antibodies; Normal distribution; Patient outcomes; Statistical analysis; Stem cells; Type 2 diabetes; Vascular endothelial growth factor; Lithuania; United States > US; South San Francisco California
• ISSN: 2090-004X; 2090-0058
• DOI: 10.1155/2021/8825082

Purpose. To assess injection patterns and vision outcomes in patients receiving intravitreal ranibizumab injections for diabetic macular edema in a real-world clinical setting. Methods. Retrospective chart review involving 74 eyes of 62 patients who started ranibizumab treatment for diabetic macular edema at the Hospital of the Lithuanian University of Health Sciences Kauno Klinikos. Data collected included follow-up visits, injections administered, and best-corrected visual acuity (BCVA). Results. Median follow-up duration was 652.5 days (min 365; max 914). Over the first year, eyes received a median of 4 injections (min 1; max 10). Among eyes with 2-year follow-up and injections during the second year, there was a median of 3 injections (min 1; max 6) over the second year. The BCVA improved by a median of 5 letters 365 ± 60 days and 730 ± 60 days after baseline. At the first visit ≥365 days after baseline, 13.5% of eyes gained ≥15 letters from baseline while 6.8% of eyes lost ≥15 letters. For 74.3% of eyes, BCVA improved (gain of ≥5 letters) or remained stable (gain/loss of ≤4 letters). Conclusion. Intravitreal ranibizumab for diabetic macular edema was effective in a real-world clinical setting, with most eyes gaining or maintaining vision. Compared with randomized prospective clinical trials, patients received less frequent injections and achieved lower vision gains.