Recent Development and Clinical Application of Cancer Vaccine: Targeting Neoantigens

• Published in: Journal of immunology research Vol. 2018; no. 2018; pp. 1 - 9
• Main Authors: Hung, Shuen-Iu, Chen, Hua-Chien, Chen, Shu-Jen, Chu, Mu-Tzu, Chung, Wen-Hung, Pan, Ren-You, Zheng, Lei
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01-01-2018; Hindawi; Hindawi Limited
• Subjects: Acid phosphatase; Adjuvants; Antigen (tumor-associated); Autoimmunity; Cancer therapies; Cancer vaccines; Chemotherapy; Clinical trials; Data processing; Dendritic cells; Deoxyribonucleic acid; DNA; Epitopes; Immunology; Immunotherapy; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Metastases; Mutation; Neoantigens; Precision medicine; Prostate cancer; Quality of life; Radiation therapy; Review; Ribonucleic acid; RNA; Surgery; Tumors; Vaccines; Viruses
• ISSN: 2314-8861; 2314-7156
• DOI: 10.1155/2018/4325874

Recently, increasing data show that immunotherapy could be a powerful weapon against cancers. Comparing to the traditional surgery, chemotherapy or radiotherapy, immunotherapy more specifically targets cancer cells, giving rise to the opportunities to the patients to have higher response rates and better quality of life and even to cure the disease. Cancer vaccines could be designed to target tumor-associated antigens (TAAs), cancer germline antigens, virus-associated antigens, or tumor-specific antigens (TSAs), which are also called neoantigens. The cancer vaccines could be cell-based (e.g., dendritic cell vaccine provenge (sipuleucel-T) targeting prostatic acid phosphatase for metastatic prostate cancer), peptide/protein-based, or gene- (DNA/RNA) based, with the different kinds of adjuvants. Neoantigens are tumor-specific and could be presented by MHC molecules and recognized by T lymphocytes, serving the ideal immune targets to increase the therapeutic specificity and decrease the risk of nonspecific autoimmunity. By targeting the shared antigens and private epitopes, the cancer vaccine has potential to treat the disease. Accordingly, personalized neoantigen-based immunotherapies are emerging. In this article, we review the literature and evidence of the advantage and application of cancer vaccine. We summarize the recent clinical trials of neoantigen cancer vaccines which were designed according to the patients’ personal mutanome. With the rapid development of personalized immunotherapy, it is believed that tumors could be efficiently controlled and become curable in the new era of precision medicine.