Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis

Neuropeptide Y (NPY) is a strong candidate gene for coronary artery disease (CAD). We have previously identified genetic linkage to familial CAD in the genomic region of NPY. We performed follow-up genetic, biostatistical, and functional analysis of NPY in early-onset CAD. In familial CAD (GENECARD,...

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Bibliographic Details
Published in:	PLoS genetics Vol. 5; no. 1; p. e1000318
Main Authors:	Shah, Svati H, Freedman, Neil J, Zhang, Lisheng, Crosslin, David R, Stone, David H, Haynes, Carol, Johnson, Jessica, Nelson, Sarah, Wang, Liyong, Connelly, Jessica J, Muehlbauer, Michael, Ginsburg, Geoffrey S, Crossman, David C, Jones, Christopher J H, Vance, Jeffery, Sketch, Michael H, Granger, Christopher B, Newgard, Christopher B, Gregory, Simon G, Goldschmidt-Clermont, Pascal J, Kraus, William E, Hauser, Elizabeth R
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-01-2009 Public Library of Science (PLoS)
Subjects:	Age Age of Onset Alleles Animals Arginine - analogs & derivatives Arginine - pharmacology Atherosclerosis Atherosclerosis - epidemiology Atherosclerosis - genetics Cardiovascular disease Cardiovascular Disorders/Coronary Artery Disease Coronary vessels Female Generalized linear models Genes Genetic aspects Genetic polymorphisms Genetic Predisposition to Disease - genetics Genetics Genetics and Genomics/Complex Traits Genotype Health aspects Heart Humans Linkage Disequilibrium Lod Score Male Mice Mice, Transgenic Middle Aged Neuropeptide Y Neuropeptide Y - genetics Pathogenesis Polymorphism, Genetic Receptors, Neuropeptide Y - antagonists & inhibitors Receptors, Neuropeptide Y - genetics Receptors, Neuropeptide Y - metabolism Risk factors Rodents United States
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