A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology

The mechanistic basis for how genetic variants cause differences in phenotypic traits is often elusive. We identified a quantitative trait locus in Caenorhabditis elegans that affects three seemingly unrelated phenotypic traits: lifetime fecundity, adult body size, and susceptibility to the human pa...

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Bibliographic Details
Published in:	PLoS genetics Vol. 10; no. 2; p. e1004156
Main Authors:	Andersen, Erik C, Bloom, Joshua S, Gerke, Justin P, Kruglyak, Leonid
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-02-2014 Public Library of Science (PLoS)
Subjects:	Alleles Animals Behavior Biology Body Size - genetics Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - growth & development Caenorhabditis elegans - microbiology Caenorhabditis elegans Proteins - genetics Female Fertility - genetics Gene expression Genetic aspects Genetic Variation Growth Humans Mutation Nematodes Neuropeptides Neuropeptides - genetics Physiological aspects Quantitative genetics Quantitative trait loci Quantitative Trait Loci - genetics Receptors, Neuropeptide Y - genetics Scholarships & fellowships Staphylococcus aureus - genetics Staphylococcus aureus - pathogenicity United States
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