Morphological mutations: lessons from the cockscomb

Mutation of gene regulatory sequences could, in principle, influence gene activity in only one or a few tissues, enabling new morphologies with beneficial effects in one organ to be selected while avoiding potentially harmful effects to other structures that might arise from coding sequence mutati...

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Bibliographic Details
Published in:	PLoS genetics Vol. 11; no. 3; p. e1004979
Main Author:	Headon, Denis
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01-03-2015 Public Library of Science (PLoS)
Subjects:	Animals Embryonic Development - genetics Gastrulation - genetics Gene expression Genes, Duplicate Genomes Identification and classification Morphology Morphology (Biology) Mutation T-Box Domain Proteins - genetics Transcription factors United States
Online Access:	Get full text
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Summary:	Mutation of gene regulatory sequences could, in principle, influence gene activity in only one or a few tissues, enabling new morphologies with beneficial effects in one organ to be selected while avoiding potentially harmful effects to other structures that might arise from coding sequence mutation [1]. The resulting ectopic expression of each transcription factor presumably amplifies the effect of the causative mutation into altered expression of many genes, thereby modifying the intercellular signalling that controls comb outgrowth [9].
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Commentary-1 The author declares that no competing interests exist.
ISSN:	1553-7404 1553-7390 1553-7404
DOI:	10.1371/journal.pgen.1004979