A remarkable age-related increase in SIRT1 protein expression against oxidative stress in elderly: SIRT1 gene variants and longevity in human

Aging is defined as the accumulation of progressive organ dysfunction. Controlling the rate of aging by clarifying the complex pathways has a significant clinical importance. Nowadays, sirtuins have become famous molecules for slowing aging and decreasing age-related disorders. In the present study,...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 3; p. e0117954
Main Authors:	Kilic, Ulkan, Gok, Ozlem, Erenberk, Ufuk, Dundaroz, Mehmet Rusen, Torun, Emel, Kucukardali, Yasar, Elibol-Can, Birsen, Uysal, Omer, Dundar, Tolga
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 18-03-2015 Public Library of Science (PLoS)
Subjects:	Adult Adults Age Aged Aged, 80 and over Aging Analysis Apoptosis Aryldialkylphosphatase - biosynthesis Aryldialkylphosphatase - genetics Biology Cardiovascular disease Child Child, Preschool Children Cholesterol Coronary vessels Diabetes Enzymes Epigenetics Female Gene expression Gene Expression Regulation, Enzymologic - physiology Genes Genetic aspects Genetic diversity Genetic polymorphisms Genotypes Geriatrics Heart attacks Humans Life span Longevity Longevity - physiology Male Medicine Metabolism Middle Aged Mortality Nitric Oxide Synthase Type III - biosynthesis Nitric Oxide Synthase Type III - genetics Older people Oxidative stress Oxidative Stress - physiology Pediatrics Phenotypic variations Polymorphism, Single Nucleotide Population studies Proteins Research methodology Single-nucleotide polymorphism SIRT1 protein Sirtuin 1 - biosynthesis Sirtuin 1 - genetics Sirtuins Studies Istanbul Turkey Turkey
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