Temporal network based analysis of cell specific vein graft transcriptome defines key pathways and hub genes in implantation injury

Vein graft failure occurs between 1 and 6 months after implantation due to obstructive intimal hyperplasia, related in part to implantation injury. The cell-specific and temporal response of the transcriptome to vein graft implantation injury was determined by transcriptional profiling of laser capt...

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Bibliographic Details
Published in:	PloS one Vol. 7; no. 6; p. e39123
Main Authors:	Bhasin, Manoj, Huang, Zhen, Pradhan-Nabzdyk, Leena, Malek, Junaid Y, LoGerfo, Philip J, Contreras, Mauricio, Guthrie, Patrick, Csizmadia, Eva, Andersen, Nicholas, Kocher, Olivier, Ferran, Christiane, LoGerfo, Frank W
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15-06-2012 Public Library of Science (PLoS)
Subjects:	Acids Algorithms Angiogenesis Animals Apoptosis Back propagation Bayesian analysis Bioinformatics Biology Biomedical engineering Cell cycle Collagen Dendritic cells Dogs Endothelial cells Extracellular matrix Gene expression Genes Genomics Glucocorticoids Graft rejection Grafting Grafts Growth factors Hyperplasia Immune response Implantation Inflammation Injury analysis Injury prevention Insulin Interdisciplinary aspects Interleukin 6 Interleukin 8 Medical schools Medicine Microscopy Mitosis Muscles Myeloid cells NF-κB protein Pathogenesis Pathways Physicians Principal components analysis Proteomics Quality Control Signaling Smooth muscle Surgery Transcription Transcriptome Vascular surgery Veins & arteries Veins - transplantation United States > US Massachusetts
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