Clinicopathological characteristics of duodenal epithelial neoplasms: Focus on tumors with a gastric mucin phenotype (pyloric gland-type tumors)

• Published in: PloS one Vol. 12; no. 4; p. e0174985
• Main Authors: Mitsuishi, Takehiro, Hamatani, Shigeharu, Hirooka, Shinichi, Fukasawa, Nei, Aizawa, Daisuke, Hara, Yuko, Dobashi, Akira, Goda, Kenichi, Fukuda, Takahiro, Saruta, Masayuki, Urashima, Mitsuyoshi, Ikegami, Masahiro
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 04-04-2017; Public Library of Science (PLoS)
• Subjects: Adenocarcinoma, Mucinous - metabolism; Adenocarcinoma, Mucinous - pathology; Adenoma - metabolism; Adenoma - pathology; Adult; Aged; Aged, 80 and over; Biology and Life Sciences; Carcinoma; Carcinoma - metabolism; Carcinoma - pathology; Classification; Differentiation; Duodenal Neoplasms - classification; Duodenal Neoplasms - metabolism; Duodenal Neoplasms - pathology; Duodenum; Endoscopy; Epithelial tumors; Female; Gastric Mucins - metabolism; Gastric Mucosa - metabolism; Gastric Mucosa - pathology; Genotype & phenotype; Glands; H(+)-K(+)-Exchanging ATPase - metabolism; Health aspects; Humans; Laboratories; Large intestine; Lesions; Male; Medicine; Medicine and Health Sciences; Middle Aged; Mucin; Mutation; Neoplasms; Pathology; Pepsinogen A - metabolism; Phenotypes; Research and Analysis Methods; Small intestine cancer; Stomach; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Tumors; United Kingdom > UK; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0174985

Epithelial tumors less commonly occur in the duodenum than in the stomach or large intestine. The clinicopathological characteristics of duodenal epithelial tumors remain a matter of debate. We therefore studied resected specimens to investigate the clinicopathological characteristics of duodenal epithelial tumors.
Among duodenal epithelial tumors resected endoscopically or surgically in our hospital, we studied the clinicopathological characteristics of 110 adenomas or intramucosal carcinomas. The grade of atypia of all tumors was classified into 3 groups according to the World Health Organization (WHO) 2010 classification. The tumors were immunohistochemically evaluated to determine the frequency of differentiation toward fundic glands.
As for patient characteristics, there were 76 men (75.2%) and 25 women (24.8%), with a median age of 65 years (range, 34 to 84). The tumors most commonly arose in the first to second part of the duodenum. Many lesions were flat, and the median tumor diameter was 8.0 mm. The lesions were classified into 2 types according to mucin phenotype: intestinal-type tumors (98 lesions, 89.1%) and gastric-type tumors (12 lesions, 10.9%). Intestinal-type tumors were subdivided into 2 groups: tubular-type tumors (91 lesions, 82.7%) and tubulovillous-type tumors (7 lesions, 6.4%). Gastric-type tumors were classified into 2 types: foveolar type (3 lesions, 2.7%) and pyloric gland-type (PG) tumors (9 lesions, 8.2%). The grade of atypia was significantly higher in gastric-type tumors (p<0.01). PG tumors were gastric-type tumors characterized by pyloric glands and findings suggesting differentiation toward fundic glands.
About 10% of the duodenal tumors had a gastric-type mucin phenotype. Gastric-type tumors showed high-grade atypia. In particular, PG tumors showed similarities to PG tumors of the stomach, such as differentiation toward fundic glands.