Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis
Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern Europe...
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| Published in: | PloS one Vol. 9; no. 3; p. e90182 |
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| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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03-03-2014
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| Abstract | Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts.
A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data.
Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: pM-H = 0.0005; ORM-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [pM-H = 0.0003, ORM-H (95% CI) = 1.32 (1.14-1.53)].
Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts. |
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| AbstractList | Background Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. Methods A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Results Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: pM-H = 0.0005; ORM-H (95% CI) = 1.27 (1.11–1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [pM-H = 0.0003, ORM-H (95% CI) = 1.32 (1.14–1.53)]. Conclusion Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts. Background Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. Methods A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Results Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: p.sub.M-H = 0.0005; OR.sub.M-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [p.sub.M-H = 0.0003, OR.sub.M-H (95% CI) = 1.32 (1.14-1.53)]. Conclusion Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts. Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: p.sub.M-H = 0.0005; OR.sub.M-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [p.sub.M-H = 0.0003, OR.sub.M-H (95% CI) = 1.32 (1.14-1.53)]. Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts. BACKGROUNDHuman endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. METHODSA single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. RESULTSSignificant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: pM-H = 0.0005; ORM-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [pM-H = 0.0003, ORM-H (95% CI) = 1.32 (1.14-1.53)]. CONCLUSIONAssociation of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts. Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: pM-H = 0.0005; ORM-H (95% CI) = 1.27 (1.11-1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [pM-H = 0.0003, ORM-H (95% CI) = 1.32 (1.14-1.53)]. Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts. Background Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV families have been integrated in the genome. HERV-Fc1 in chromosome X has been previously associated with multiple sclerosis (MS) in Northern European populations. Additionally, HERV-Fc1 RNA levels of expression have been found increased in plasma of MS patients with active disease. Considering the North-South latitude gradient in MS prevalence, we aimed to evaluate the role of HERV-Fc1on MS risk in three independent Spanish cohorts. Methods A single nucleotide polymorphism near HERV-Fc1, rs391745, was genotyped by Taqman chemistry in a total of 2473 MS patients and 3031 ethnically matched controls, consecutively recruited from: Northern (569 patients and 980 controls), Central (883 patients and 692 controls) and Southern (1021 patients and 1359 controls) Spain. Our results were pooled in a meta-analysis with previously published data. Results Significant associations of the HERV-Fc1 polymorphism with MS were observed in two Spanish cohorts and the combined meta-analysis with previous data yielded a significant association [rs391745 C-allele carriers: pM-H = 0.0005; ORM-H (95% CI) = 1.27 (1.11–1.45)]. Concordantly to previous findings, when the analysis was restricted to relapsing remitting and secondary progressive MS samples, a slight enhancement in the strength of the association was observed [pM-H = 0.0003, ORM-H (95% CI) = 1.32 (1.14–1.53)]. Conclusion Association of the HERV-Fc1 polymorphism rs391745 with bout-onset MS susceptibility was confirmed in Southern European cohorts. |
| Audience | Academic |
| Author | Alcina, Antonio Leyva, Laura Astobiza, Ianire Arroyo, Rafael Fernández, Oscar Antigüedad, Alfredo Izquierdo, Guillermo Matesanz, Fuencisla Vandenbroeck, Koen Álvarez-Lafuente, Roberto Urcelay, Elena de la Hera, Belén Alloza, Iraide Fedetz, María García-Montojo, Marta Varadé, Jezabel |
| AuthorAffiliation | 1 Immunology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain 7 Unidad de Esclerosis Múltiple, Hospital Virgen Macarena, Sevilla, Spain 3 Instituto de Parasitología y Biomedicina “López Neyra”, Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain Hospital Nacional de Parapléjicos – SESCAM, Spain 4 Neurogenomiks Group, Universidad del País Vasco (UPV/EHU), Leioa, Spain 5 Laboratorio de Investigación, Instituto de Neurociencias Clínicas, Hospital Regional Universitario, Málaga, Spain 9 Achucarro Basque Center for Neuroscience – UPV/EHU, Zamudio, Spain 8 Servicio de Neurología, Hospital de Basurto, Bilbao, Spain 10 IKERBASQUE, Basque Foundation for Science, Bilbao, Spain 2 Multiple Sclerosis Unit, Neurology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain 6 Servicio de Neurología, Instituto de Neurociencias Clínicas, Hospit |
| AuthorAffiliation_xml | – name: 9 Achucarro Basque Center for Neuroscience – UPV/EHU, Zamudio, Spain – name: 6 Servicio de Neurología, Instituto de Neurociencias Clínicas, Hospital Regional Universitario, Málaga, Spain – name: 7 Unidad de Esclerosis Múltiple, Hospital Virgen Macarena, Sevilla, Spain – name: 3 Instituto de Parasitología y Biomedicina “López Neyra”, Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain – name: 4 Neurogenomiks Group, Universidad del País Vasco (UPV/EHU), Leioa, Spain – name: Hospital Nacional de Parapléjicos – SESCAM, Spain – name: 10 IKERBASQUE, Basque Foundation for Science, Bilbao, Spain – name: 2 Multiple Sclerosis Unit, Neurology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain – name: 8 Servicio de Neurología, Hospital de Basurto, Bilbao, Spain – name: 5 Laboratorio de Investigación, Instituto de Neurociencias Clínicas, Hospital Regional Universitario, Málaga, Spain – name: 1 Immunology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain |
| Author_xml | – sequence: 1 givenname: Belén surname: de la Hera fullname: de la Hera, Belén organization: Immunology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain – sequence: 2 givenname: Jezabel surname: Varadé fullname: Varadé, Jezabel organization: Immunology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain – sequence: 3 givenname: Marta surname: García-Montojo fullname: García-Montojo, Marta organization: Multiple Sclerosis Unit, Neurology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain – sequence: 4 givenname: Antonio surname: Alcina fullname: Alcina, Antonio organization: Instituto de Parasitología y Biomedicina "López Neyra", Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain – sequence: 5 givenname: María surname: Fedetz fullname: Fedetz, María organization: Instituto de Parasitología y Biomedicina "López Neyra", Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain – sequence: 6 givenname: Iraide surname: Alloza fullname: Alloza, Iraide organization: Neurogenomiks Group, Universidad del País Vasco (UPV/EHU), Leioa, Spain – sequence: 7 givenname: Ianire surname: Astobiza fullname: Astobiza, Ianire organization: Neurogenomiks Group, Universidad del País Vasco (UPV/EHU), Leioa, Spain – sequence: 8 givenname: Laura surname: Leyva fullname: Leyva, Laura organization: Laboratorio de Investigación, Instituto de Neurociencias Clínicas, Hospital Regional Universitario, Málaga, Spain – sequence: 9 givenname: Oscar surname: Fernández fullname: Fernández, Oscar organization: Servicio de Neurología, Instituto de Neurociencias Clínicas, Hospital Regional Universitario, Málaga, Spain – sequence: 10 givenname: Guillermo surname: Izquierdo fullname: Izquierdo, Guillermo organization: Unidad de Esclerosis Múltiple, Hospital Virgen Macarena, Sevilla, Spain – sequence: 11 givenname: Alfredo surname: Antigüedad fullname: Antigüedad, Alfredo organization: Servicio de Neurología, Hospital de Basurto, Bilbao, Spain – sequence: 12 givenname: Rafael surname: Arroyo fullname: Arroyo, Rafael organization: Multiple Sclerosis Unit, Neurology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain – sequence: 13 givenname: Roberto surname: Álvarez-Lafuente fullname: Álvarez-Lafuente, Roberto organization: Multiple Sclerosis Unit, Neurology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain – sequence: 14 givenname: Koen surname: Vandenbroeck fullname: Vandenbroeck, Koen organization: Neurogenomiks Group, Universidad del País Vasco (UPV/EHU), Leioa, Spain; Achucarro Basque Center for Neuroscience - UPV/EHU, Zamudio, Spain; IKERBASQUE, Basque Foundation for Science, Bilbao, Spain – sequence: 15 givenname: Fuencisla surname: Matesanz fullname: Matesanz, Fuencisla organization: Instituto de Parasitología y Biomedicina "López Neyra", Consejo Superior de Investigaciones Científicas (CSIC), Granada, Spain – sequence: 16 givenname: Elena surname: Urcelay fullname: Urcelay, Elena organization: Immunology Dept., Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/24594754$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2014 Public Library of Science 2014 de la Hera et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2014 de la Hera et al 2014 de la Hera et al |
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| DOI | 10.1371/journal.pone.0090182 |
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| DocumentTitleAlternate | HERV-Fc1 Association with MS Risk: A Meta-Analysis |
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| Editor | de Castro, Fernando |
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| Issue | 3 |
| Language | English |
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| Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 Conceived and designed the experiments: KV FM EU. Performed the experiments: BDLH JV MGM MF IA. Analyzed the data: AA IA LL RAL. Contributed reagents/materials/analysis tools: OF GI AA RA. Wrote the paper: KV FM EU. Competing Interests: The authors have declared that no competing interests exist. |
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| Snippet | Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different HERV... Background Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different... BACKGROUNDHuman endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different... BACKGROUND: Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different... Background Human endogenous retroviruses (HERVs) are repetitive sequences derived from ancestral germ-line infections by exogenous retroviruses and different... |
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| SubjectTerms | Adult Biology Cohort Studies Development and progression Disease Susceptibility Endogenous Retroviruses - isolation & purification Female Genetic aspects Genomics Health aspects Humans Infection Male Mathematics Medicine Meta-analysis Middle Aged Multiple sclerosis Multiple Sclerosis - virology Single nucleotide polymorphisms |
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| Title | Human endogenous retrovirus HERV-Fc1 association with multiple sclerosis susceptibility: a meta-analysis |
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