Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts

Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, the vast majority of long-term childhood cancer survivors will develop a chronic health condition caused by their successful treatments and severe cardiac...

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Bibliographic Details
Published in:	PloS one Vol. 15; no. 9; p. e0238856
Main Authors:	Mancilla, T R, Davis, L R, Aune, G J
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 22-09-2020 Public Library of Science (PLoS)
Subjects:	Animals Anthracycline Antibiotics, Antineoplastic - pharmacology Anticancer properties Biology and Life Sciences Cancer Cardiomyopathy Cardiotoxicity Cardiotoxicity - pathology Cardiotoxicity - prevention & control Cell adhesion & migration Cell cycle Cell migration Cellular stress response Chemotherapy Childhood cancer Children Chronic fatigue syndrome Complications and side effects Coronary artery disease Critical components Cytotoxicity Damage Deoxyribonucleic acid Dilated cardiomyopathy DNA DNA damage Doxorubicin Doxorubicin - pharmacology Drug therapy Extracellular matrix Fibroblasts Fibroblasts - drug effects Fibroblasts - metabolism Fibroblasts - pathology Flow cytometry Gene expression Genetic aspects Health aspects Heart Heart cells Heart diseases Injury prevention Laboratory animals Localization Medical research Medical treatment Medicine and Health Sciences Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondria - pathology Mitochondrial DNA Mitophagy Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology p53 Protein Parkin protein Pediatric research Pediatrics Physiological aspects Quality of life Research and Analysis Methods Risk factors Tumor proteins Tumor Suppressor Protein p53 - physiology United States United States > US
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