The characteristic changes in hepatitis B virus x region for hepatocellular carcinoma: a comprehensive analysis based on global data

Mutations in hepatitis B virus (HBV) X region (HBx) play important roles in hepatocarcinogenesis while the results remain controversial. We sought to clarify potential hepatocellular carcinoma (HCC)-characteristic mutations in HBx from HBV genotype C-infected patients and the distribution of those m...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 5; p. e0125555
Main Authors:	Li, Wenwen, Goto, Kaku, Matsubara, Yasuo, Ito, Sayaka, Muroyama, Ryosuke, Li, Qiang, Kato, Naoya
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 05-05-2015 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Aged Aged, 80 and over Analysis Antigens Apoptosis Binding sites Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - etiology Cell Transformation, Viral Child Child, Preschool Computational Biology Databases, Nucleic Acid Deoxyribonucleic acid DNA Epitopes Female Gene mutation Genetic aspects Genomes Genotype Genotype & phenotype Genotypes Global Health Health aspects Hepatitis Hepatitis B Hepatitis B - complications Hepatitis B - virology Hepatitis B virus Hepatitis B virus - genetics Hepatocellular carcinoma Humans Infections Liver cancer Liver diseases Liver Neoplasms - epidemiology Liver Neoplasms - etiology Male Medicine Middle Aged miRNA Mutation Patients Phases Proteins Regression analysis Risk Risk analysis Risk factors Science Trans-Activators - chemistry Trans-Activators - genetics Viruses Young Adult China
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