MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells

The Map kinase Activating Death Domain containing protein (MADD) isoform of the IG20 gene is over-expressed in different types of cancer tissues and cell lines and it functions as a negative regulator of apoptosis. Therefore, we speculated that MADD might be over-expressed in human breast cancer tis...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 2; p. e56817
Main Authors:	Turner, Andrea, Li, Liang-Cheng, Pilli, Tania, Qian, Lixia, Wiley, Elizabeth Louise, Setty, Suman, Christov, Konstantin, Ganesh, Lakshmy, Maker, Ajay V, Li, Peifeng, Kanteti, Prasad, Das Gupta, Tapas K, Prabhakar, Bellur S
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 15-02-2013 Public Library of Science (PLoS)
Subjects:	Amino Acid Sequence Analysis Anthracyclines Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Biology Biotechnology Breast cancer Breast Neoplasms - pathology Cancer Cancer cells Cancer therapies Carcinoma Caspase Caspase-8 Cell death Cell Line, Tumor Chemotherapy Cytotoxicity Death Domain Receptor Signaling Adaptor Proteins - chemistry Death Domain Receptor Signaling Adaptor Proteins - deficiency Death Domain Receptor Signaling Adaptor Proteins - genetics DNA microarrays Doxorubicin Doxorubicin - pharmacology Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Guanine Nucleotide Exchange Factors - chemistry Guanine Nucleotide Exchange Factors - deficiency Guanine Nucleotide Exchange Factors - genetics Humans Immunology Invasiveness Kinases Ligands MAP kinase Medicine Molecular Sequence Data Mortality Overexpression Proteins Receptors, Death Domain - metabolism Recruitment RNA, Small Interfering - genetics Synergism Tissues TNF-Related Apoptosis-Inducing Ligand - pharmacology TRAIL protein Tumor cell lines Tumor necrosis factor-TNF Illinois Chicago Illinois
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