Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics

Vascular endothelial growth factor-A (VEGF) is produced by most cancer cells as multiple isoforms, which display distinct biological activities. VEGF plays an undisputed role in tumour growth, vascularisation and metastasis; nevertheless the functions of individual isoforms in these processes remain...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 8; p. e104015
Main Authors:	Kanthou, Chryso, Dachs, Gabi U, Lefley, Diane V, Steele, Andrew J, Coralli-Foxon, Claudia, Harris, Sheila, Greco, Olga, Dos Santos, Sofia A, Reyes-Aldasoro, Constantino C, English, William R, Tozer, Gillian M
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 13-08-2014 Public Library of Science (PLoS)
Subjects:	AKT protein Angiogenesis Animals Apoptosis Biology and life sciences Biomarkers Cancer Carcinogenesis - genetics Cell Adhesion Cell growth Cell Line, Tumor Cell migration Cell Movement - genetics Cell Proliferation - genetics Cell survival Cell Survival - genetics Collagen Contractility Cyclin-dependent kinase Cyclin-dependent kinase inhibitor p27 Elongation Enzyme inhibitors Extracellular signal-regulated kinase Fibroblasts Fibrosarcoma Fibrosarcoma - metabolism Fibrosarcoma - pathology Forkhead protein Gene Expression Regulation, Neoplastic Growth Isoforms Kinases Localization Medical prognosis Medical research Medicine Medicine and Health Sciences Mesenchyme Metastases Metastasis Mice Motility Neoplasm Metastasis - genetics Oncology Overexpression Protein Isoforms - chemistry Protein Isoforms - metabolism Protein-tyrosine kinase receptors Proteins Receptor mechanisms Receptors Receptors, Vascular Endothelial Growth Factor - metabolism Rodents Sarcoma Signaling Stat3 protein Stem cells Transgenic animals Tumors Tyrosine Vascular endothelial growth factor Vascular Endothelial Growth Factor A - chemistry Vascular Endothelial Growth Factor A - metabolism United Kingdom > UK
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