Maternal pravastatin prevents altered fetal brain development in a preeclamptic CD-1 mouse model

Using an animal model, we have previously shown that preeclampsia results in long-term adverse neuromotor outcomes in the offspring, and this phenotype was prevented by antenatal treatment with pravastatin. This study aims to localize the altered neuromotor programming in this animal model and to ev...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 6; p. e100873
Main Authors:	Carver, Alissa R, Andrikopoulou, Maria, Lei, Jun, Tamayo, Esther, Gamble, Phyllis, Hou, Zhipeng, Zhang, Jiangyang, Mori, Susumu, Saade, George R, Costantine, Maged M, Burd, Irina
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25-06-2014 Public Library of Science (PLoS)
Subjects:	Adenoviruses Anatomy Animal models Animals Antilipemic agents Biology and Life Sciences Bore Brain Brain - cytology Brain - drug effects Brain - metabolism Brain architecture Brain Mapping Brain research Colliculus Cytochemistry Disease Models, Animal Epigenetics Female Fetal Development - drug effects Fetus - cytology Fetus - drug effects Fetus - metabolism Fetuses Fornix Gender differences Gene expression Globus pallidus Gynecology Hypertension Hypoxia Image acquisition Image Processing, Computer-Assisted Immunoenzyme Techniques Immunoglobulins Inferior colliculus Laboratory animals Magnetic resonance Magnetic Resonance Imaging Male Males Medicine Medicine and Health Sciences Mice Neocortex Neuroimaging Obstetrics Offspring Pravastatin Pravastatin - pharmacology Pre-eclampsia Pre-Eclampsia - metabolism Pre-Eclampsia - pathology Pre-Eclampsia - prevention & control Preeclampsia Pregnancy Pregnant women Progeny Radiology Rodents Stains Statins Statistical analysis Stria medullaris Stroke Systematic review Thalamus Tidal bores Traumatic brain injury Variance analysis Vascular endothelial growth factor Vascular Endothelial Growth Factor Receptor-1 - genetics Vascular Endothelial Growth Factor Receptor-1 - metabolism Viruses Weaning
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