Intrahepatic Cholestasis of Pregnancy (ICP) in U.S. Latinas and Chileans: Clinical features, Ancestry Analysis, and Admixture Mapping

In the Americas, women with Indigenous American ancestry are at increased risk of intrahepatic cholestasis of pregnancy (ICP), relative to women of other ethnicities. We hypothesized that ancestry-related genetic factors contribute to this increased risk. We collected clinical and laboratory data, a...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 6; p. e0131211
Main Authors:	Bull, Laura N, Hu, Donglei, Shah, Sohela, Temple, Luisa, Silva, Karla, Huntsman, Scott, Melgar, Jennifer, Geiser, Mary T, Sanford, Ukina, Ortiz, Juan A, Lee, Richard H, Kusanovic, Juan P, Ziv, Elad, Vargas, Juan E
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 30-06-2015 Public Library of Science (PLoS)
Subjects:	Admixtures Adult Alanine Transaminase - blood Aspartate Aminotransferases - blood Bile Acids and Salts - blood Bilirubin - blood Bioinformatics Case-Control Studies Chile Cholestasis Cholestasis, Intrahepatic - blood Cholestasis, Intrahepatic - diagnosis Cholestasis, Intrahepatic - genetics Chromosome 2 Chromosomes Chromosomes, Human, Pair 2 - genetics Comparative analysis Confidence intervals Female Gallbladder diseases gamma-Glutamyltransferase - blood Gene loci Gene mapping Genetic factors Genetic Predisposition to Disease Genetics Genomes Genomics Genotyping Gynecology Hepatology Hispanic or Latino - genetics Hospitals Humans Internal medicine Laboratories Liver Mapping Medicine Minority & ethnic groups Obstetrics Polymorphism, Single Nucleotide Pregnancy Pregnancy Complications - blood Pregnancy Complications - diagnosis Pregnancy Complications - genetics Pregnant women Risk Risk Factors Single-nucleotide polymorphism Studies United States Womens health Young Adult Chile United States Los Angeles California San Francisco California California United States > US
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