Fitness peaks of dengue virus populations
The role of intra-host genetic diversity in dengue viral populations remains a topic of debate, particularly the impact on transmission of changes in this diversity. Several approaches have been taken to increasing and decreasing the genetic diversity of populations of RNA viruses and have drawn wha...
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| Published in: | PloS one Vol. 13; no. 1; p. e0189554 |
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02-01-2018
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| Abstract | The role of intra-host genetic diversity in dengue viral populations remains a topic of debate, particularly the impact on transmission of changes in this diversity. Several approaches have been taken to increasing and decreasing the genetic diversity of populations of RNA viruses and have drawn what appear to be contradictory conclusions. A 2-6 fold increase in genetic diversity of a wild type population of dengue virus serotype 1(DENV1) and of an infectious clone population derived from the wild type population, produced by treatment with nucleotide analogue 5 fluorouracil (5FU), drove the populations to extinction. Removal of 5FU immediately prior to extinction, resulted in a return to pre-treatment levels of fitness and genetic diversity, albeit with novel single nucleotide polymorphisms. These observations support the concept that DENV populations exist on fitness peaks determined by their transmission requirements and either an increase or a decrease in genetic diversity may result in a loss of fitness. |
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| AbstractList | The role of intra-host genetic diversity in dengue viral populations remains a topic of debate, particularly the impact on transmission of changes in this diversity. Several approaches have been taken to increasing and decreasing the genetic diversity of populations of RNA viruses and have drawn what appear to be contradictory conclusions. A 2–6 fold increase in genetic diversity of a wild type population of dengue virus serotype 1(DENV1) and of an infectious clone population derived from the wild type population, produced by treatment with nucleotide analogue 5 fluorouracil (5FU), drove the populations to extinction. Removal of 5FU immediately prior to extinction, resulted in a return to pre-treatment levels of fitness and genetic diversity, albeit with novel single nucleotide polymorphisms. These observations support the concept that DENV populations exist on fitness peaks determined by their transmission requirements and either an increase or a decrease in genetic diversity may result in a loss of fitness. |
| Audience | Academic |
| Author | Liu, Wen Jun Aaskov, John G |
| AuthorAffiliation | University of Hong Kong, HONG KONG 2 Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Australia 1 Australian Army Malaria Institute, Weary Dunlop Drive, Enoggera, Brisbane, Australia |
| AuthorAffiliation_xml | – name: 2 Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Australia – name: 1 Australian Army Malaria Institute, Weary Dunlop Drive, Enoggera, Brisbane, Australia – name: University of Hong Kong, HONG KONG |
| Author_xml | – sequence: 1 givenname: Wen Jun surname: Liu fullname: Liu, Wen Jun organization: Australian Army Malaria Institute, Weary Dunlop Drive, Enoggera, Brisbane, Australia – sequence: 2 givenname: John G orcidid: 0000-0003-1998-4575 surname: Aaskov fullname: Aaskov, John G organization: Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Australia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29293524$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1186_s13071_021_04631_7 crossref_primary_10_1128_AAC_00380_18 crossref_primary_10_1016_j_bjid_2019_11_003 crossref_primary_10_1371_journal_pntd_0006421 crossref_primary_10_3390_v13010108 crossref_primary_10_1111_tmi_13311 |
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| Copyright | COPYRIGHT 2018 Public Library of Science 2018 Liu, Aaskov. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2018 Liu, Aaskov 2018 Liu, Aaskov |
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| Title | Fitness peaks of dengue virus populations |
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