Applying mathematical tools to accelerate vaccine development: modeling Shigella immune dynamics

We establish a mathematical framework for studying immune interactions with Shigella, a bacteria that kills over one million people worldwide every year. The long-term goal of this novel approach is to inform Shigella vaccine design by elucidating which immune components and bacterial targets are cr...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 4; p. e59465
Main Authors:	Davis, Courtney L, Wahid, Rezwanul, Toapanta, Franklin R, Simon, Jakub K, Sztein, Marcelo B, Levy, Doron
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 02-04-2013 Public Library of Science (PLoS)
Subjects:	Algorithms Antibiotics Antibodies Antibodies, Bacterial - immunology Antigens Bacteria Bacterial infections Biology Cell death Computer Simulation Cytokines Differential equations Disease Dysentery, Bacillary - immunology Dysentery, Bacillary - prevention & control E coli Host-Pathogen Interactions - immunology Humans Immune system Immunity Immunoglobulin A Immunoglobulin G Immunological memory Immunology Infections Intestinal Mucosa - immunology Intestinal Mucosa - microbiology Lipopolysaccharides Lymphatic system Lymphocytes Lymphocytes B Mathematical analysis Mathematical models Mathematics Medicine Models, Immunological Pathogens Proteins Rodents Shigella Shigella - immunology Shigella Vaccines - immunology Shigellosis Surface antigens Vaccine development Vaccines United States > US Maryland Baltimore Maryland
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