Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells

Breast cancers that express estrogen receptor alpha (ERα+) constitute the majority of breast tumors. Estrogen is a major driver of their growth, and targeting ER-mediated signals is a largely successful primary therapeutic strategy. Nonetheless, ERα+ tumors also result in the most breast cancer mort...

Full description

Saved in:

Bibliographic Details
Published in:	PloS one Vol. 10; no. 1; p. e0116891
Main Authors:	Barcus, Craig E, Holt, Elizabeth C, Keely, Patricia J, Eliceiri, Kevin W, Schuler, Linda A
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 21-01-2015 Public Library of Science (PLoS)
Subjects:	17β-Estradiol Binding sites Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cell Culture Techniques Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Clinical outcomes Collagen Collagen Type I - genetics Collagen Type I - metabolism Crosstalk Density Estradiol - metabolism Estradiol - pharmacology Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Extracellular matrix Extracellular Matrix - genetics Extracellular Matrix - metabolism Extracellular Matrix - pathology Female Fibers Gene Expression Regulation, Neoplastic - drug effects Genomes Health aspects Hormones Humans Kinases Laboratories MCF-7 Cells Metastasis Molecular biology Mortality Phenols (Class of compounds) Prolactin Prolactin - metabolism Prolactin - pharmacology Receptors, Prolactin - metabolism Sex hormones Tumor cell lines Tumors
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!