Inactivated Eyedrop Influenza Vaccine Adjuvanted with Poly(I:C) Is Safe and Effective for Inducing Protective Systemic and Mucosal Immunity

The eye route has been evaluated as an efficient vaccine delivery routes. However, in order to induce sufficient antibody production with inactivated vaccine, testing of the safety and efficacy of the use of inactivated antigen plus adjuvant is needed. Here, we assessed various types of adjuvants in...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 9; p. e0137608
Main Authors:	Kim, Eun-Do, Han, Soo Jung, Byun, Young-Ho, Yoon, Sang Chul, Choi, Kyoung Sub, Seong, Baik Lin, Seo, Kyoung Yul
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 10-09-2015 Public Library of Science (PLoS)
Subjects:	Adjuvants Adjuvants, Immunologic Administration, Intranasal Animals Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Formation - immunology Antigens Antigens, Viral - immunology Brain Brain research Cholera Cholera toxin Conjunctiva Cytokines Dendritic cells Dose-Response Relationship, Immunologic Drug delivery systems Engineering schools Eye FDA approval Female Gene expression Hemagglutinins Homology Hospitals Humans Immunity Immunity, Mucosal Immunization Immunoglobulin A Immunoglobulin G Immunoglobulin G - blood Immunoglobulin G - immunology Immunoglobulins Infections Infiltration Inflammation Influenza Influenza A Influenza A Virus, H1N1 Subtype - immunology Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - adverse effects Influenza Vaccines - immunology Inoculation Interleukin 6 Leukocytes (mononuclear) Medicine Methods Mice Mucosal immunity Mucous membrane Olfactory bulb Ophthalmic Solutions - administration & dosage Ophthalmic Solutions - adverse effects Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Physiological aspects Poly I-C Polyinosinic:polycytidylic acid Prevention Public health Rodents Salmonella Vaccination Vaccines Vaccines, Inactivated Viral infections Viruses Water-borne diseases Waterborne diseases South Korea
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