Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma

The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but the role of Fli-1 in T cell development has not been closely examined. To address this we retrovirally overexpressed Fli-1 in various in vitro and in vivo settings and a...

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Published in:	PloS one Vol. 8; no. 5; p. e62346
Main Authors:	Smeets, Monique F M A, Chan, Angela C, Dagger, Samantha, Bradley, Cara K, Wei, Andrew, Izon, David J
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 07-05-2013 Public Library of Science (PLoS)
Subjects:	Animals Apoptosis B cells Bcl-2 protein Biology Bone marrow Cancer Carcinogenesis - immunology CD4 antigen CD8 antigen Deregulation ETS protein FLI-1 protein Flow cytometry Gene Expression Genes Genomes Hematology Hematopoietic Stem Cells - metabolism Hemopoiesis Humans Immunoglobulins Immunology Intracellular Space - genetics Leukemia Liver transplants Lymphatic system Lymphocytes Lymphocytes T Lymphoma Medicine Mice Mice, Inbred C57BL Mutation Notch1 protein Organ Specificity Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Proto-Oncogene Protein c-fli-1 - genetics Proto-Oncogene Proteins c-bcl-2 - genetics Receptor, Notch1 - genetics RNA, Messenger - genetics Signal transduction Signaling Spleen Stem cell transplantation T cell receptors T cells T-Lymphocytes - cytology T-Lymphocytes - immunology Target recognition Tissues Transcription factors Tumors Up-Regulation - immunology
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Abstract	The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but the role of Fli-1 in T cell development has not been closely examined. To address this we retrovirally overexpressed Fli-1 in various in vitro and in vivo settings and analysed its effect on T cell development. We found that Fli-1 overexpression perturbed the DN to DP transition and inhibited CD4 development whilst enhancing CD8 development both in vitro and in vivo. Surprisingly, Fli-1 overexpression in vivo eventuated in development of pre-T cell lymphoblastic leukaemia/lymphoma (pre-T LBL). Known Fli-1 target genes such as the pro-survival Bcl-2 family members were not found to be upregulated. In contrast, we found increased NOTCH1 expression in all Fli-1 T cells and detected Notch1 mutations in all tumours. These data show a novel function for Fli-1 in T cell development and leukaemogenesis and provide a new mouse model of pre-T LBL to identify treatment options that target the Fli-1 and Notch1 signalling pathways.
AbstractList	The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but the role of Fli-1 in T cell development has not been closely examined. To address this we retrovirally overexpressed Fli-1 in various in vitro and in vivo settings and analysed its effect on T cell development. We found that Fli-1 overexpression perturbed the DN to DP transition and inhibited CD4 development whilst enhancing CD8 development both in vitro and in vivo. Surprisingly, Fli-1 overexpression in vivo eventuated in development of pre-T cell lymphoblastic leukaemia/lymphoma (pre-T LBL). Known Fli-1 target genes such as the pro-survival Bcl-2 family members were not found to be upregulated. In contrast, we found increased NOTCH1 expression in all Fli-1 T cells and detected Notch1 mutations in all tumours. These data show a novel function for Fli-1 in T cell development and leukaemogenesis and provide a new mouse model of pre-T LBL to identify treatment options that target the Fli-1 and Notch1 signalling pathways. The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but the role of Fli-1 in T cell development has not been closely examined. To address this we retrovirally overexpressed Fli-1 in various in vitro and in vivo settings and analysed its effect on T cell development. We found that Fli-1 overexpression perturbed the DN to DP transition and inhibited CD4 development whilst enhancing CD8 development both in vitro and in vivo . Surprisingly, Fli-1 overexpression in vivo eventuated in development of pre-T cell lymphoblastic leukaemia/lymphoma (pre-T LBL). Known Fli-1 target genes such as the pro-survival Bcl-2 family members were not found to be upregulated. In contrast, we found increased NOTCH1 expression in all Fli-1 T cells and detected Notch1 mutations in all tumours. These data show a novel function for Fli-1 in T cell development and leukaemogenesis and provide a new mouse model of pre-T LBL to identify treatment options that target the Fli-1 and Notch1 signalling pathways.
Audience	Academic
Author	Bradley, Cara K Smeets, Monique F M A Wei, Andrew Dagger, Samantha Chan, Angela C Izon, David J
AuthorAffiliation	Purdue University, United States of America 4 Gennea, Sydney, New South Wales, Australia 2 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia 1 Haematology and Leukaemia Unit, St. Vincent’s Institute, University of Melbourne, Fitzroy, Victoria, Australia 5 Department of Clinical Haematology, The Alfred Hospital and The Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia 3 School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia
AuthorAffiliation_xml	– name: Purdue University, United States of America – name: 4 Gennea, Sydney, New South Wales, Australia – name: 1 Haematology and Leukaemia Unit, St. Vincent’s Institute, University of Melbourne, Fitzroy, Victoria, Australia – name: 2 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia – name: 3 School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia – name: 5 Department of Clinical Haematology, The Alfred Hospital and The Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/23667468$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1101/gad.5.6.908 10.1084/jem.186.2.173 10.1016/S1074-7613(01)00107-8 10.1074/jbc.M704981200 10.1242/dev.126.14.3131 10.1182/blood-2010-05-286658 10.1093/intimm/1.6.605 10.1002/eji.200323461 10.1097/00000478-200012000-00010 10.1038/sj.onc.1202534 10.1200/JCO.2005.05.047 10.1182/blood-2005-06-2553 10.1111/j.1365-2133.2007.08427.x 10.1016/j.ccr.2010.09.009 10.1128/MCB.15.12.6961 10.4049/jimmunol.152.10.4783 10.1016/j.stem.2010.07.016 10.1038/sj.emboj.7600017 10.1073/pnas.93.10.4683 10.1182/blood-2007-11-120535 10.1182/blood-2005-08-3482 10.1111/j.1600-0560.2006.00535.x 10.1182/blood-2011-10-388504 10.1016/j.cub.2008.07.048 10.1038/ni1008-1091 10.1136/jcp.2006.039230 10.1182/blood-2003-12-4345 10.4049/jimmunol.181.3.1644 10.1182/blood-2010-02-270405 10.1093/nar/19.15.4293 10.1038/nature06839 10.1126/science.1102160 10.1056/NEJM199408043310503 10.1101/gad.1897910 10.1007/BF02994008 10.1006/smim.2000.0260 10.1084/jem.184.3.903 10.1016/S1074-7613(02)00474-0 10.1038/nature06840 10.1016/j.ccr.2004.05.023 10.1073/pnas.88.9.3977 10.1182/blood-2010-05-286328 10.1182/blood-2006-12-063644 10.1128/MCB.17.8.4782 10.1016/j.immuni.2011.06.013 10.1016/S1074-7613(00)80053-9 10.1016/0092-8674(95)90170-1 10.1182/blood-2005-09-3551 10.1182/blood-2005-07-3013 10.1038/ni.2086 10.1016/S0167-5699(00)01744-8 10.1101/gad.1793709 10.1093/jnci/djr156 10.1182/blood-2004-08-3087
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Copyright	COPYRIGHT 2013 Public Library of Science 2013 Smeets et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2013 Smeets et al 2013 Smeets et al
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Notes	Competing Interests: The authors have the following interest. Cara K. Bradley is affiliated to Gennea. There are no patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors. Conceived and designed the experiments: DJI MS. Performed the experiments: DJI MS AC SD CB. Analyzed the data: DJI MS AC SD CB AW. Contributed reagents/materials/analysis tools: CB. Wrote the paper: DJI MS AC SD CB AW.
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References	21903424 - Immunity. 2011 Sep 23;35(3):413-25 10367899 - Immunity. 1999 May;10(5):537-46 22829238 - Blood Cancer J. 2012 Jan;2(1):e54 16965340 - J Cutan Pathol. 2006 Sep;33(9):642-5 15472075 - Science. 2004 Oct 8;306(5694):269-71 16166587 - Blood. 2006 Jan 15;107(2):781-5 7585946 - Cell. 1995 Oct 20;83(2):289-99 20951945 - Cancer Cell. 2010 Oct 19;18(4):353-66 21857655 - Nat Immunol. 2011 Oct;12(10):992-1001 19605688 - Genes Dev. 2009 Jul 15;23(14):1665-76 17698635 - Blood. 2007 Nov 15;110(10):3753-62 7566971 - Oncogene. 1995 Sep 21;11(6):1113-23 2518729 - Int Immunol. 1989;1(6):605-12 17962192 - J Biol Chem. 2008 Jan 11;283(2):684-92 8022439 - N Engl J Med. 1994 Aug 4;331(5):294-9 16917000 - J Clin Pathol. 2007 Jun;60(6):694-700 11114425 - Immunol Today. 2000 Dec;21(12):637-44 16621969 - Blood. 2006 Aug 1;108(3):986-92 11290335 - Immunity. 2001 Mar;14(3):253-64 18198345 - Blood. 2008 Apr 15;111(8):3941-67 14685278 - EMBO J. 2004 Jan 14;23(1):202-11 11503960 - Int J Hematol. 2001 Jun;73(4):463-8 8524263 - Mol Cell Biol. 1995 Dec;15(12):6961-70 20852131 - Blood. 2010 Dec 16;116(25):5455-64 9234734 - Mol Cell Biol. 1997 Aug;17(8):4782-91 15193261 - Cancer Cell. 2004 Jun;5(6):587-96 15367440 - Blood. 2005 Jan 1;105(1):95-102 18641300 - J Immunol. 2008 Aug 1;181(3):1644-54 18241263 - Br J Dermatol. 2008 Apr;158(4):747-53 18800157 - Nat Immunol. 2008 Oct;9(10):1091-4 18718762 - Curr Biol. 2008 Aug 26;18(16):1234-40 18401412 - Nature. 2008 Apr 10;452(7188):768-72 10375504 - Development. 1999 Jun;126(14):3131-48 20733157 - Blood. 2010 Dec 2;116(23):4795-805 20829372 - Blood. 2010 Dec 16;116(25):5443-54 22510873 - Blood. 2012 May 31;119(22):5211-4 18401411 - Nature. 2008 Apr 10;452(7188):764-7 20516195 - Genes Dev. 2010 Jun 1;24(11):1093-105 9064350 - J Exp Med. 1996 Sep 1;184(3):903-11 21653923 - J Natl Cancer Inst. 2011 Jun 22;103(12):962-78 1870982 - Nucleic Acids Res. 1991 Aug 11;19(15):4293 9221746 - J Exp Med. 1997 Jul 21;186(2):173-82 16449526 - Blood. 2006 May 15;107(10):4115-21 15522952 - Blood. 2005 Mar 1;105(5):1930-6 7513723 - J Immunol. 1994 May 15;152(10):4783-92 10102630 - Oncogene. 1999 Feb 25;18(8):1597-608 11117787 - Am J Surg Pathol. 2000 Dec;24(12):1657-62 1708890 - Proc Natl Acad Sci U S A. 1991 May 1;88(9):3977-81 20887958 - Cell Stem Cell. 2010 Oct 8;7(4):532-44 16282337 - Blood. 2006 Mar 15;107(6):2540-3 11085178 - Semin Immunol. 2000 Oct;12(5):457-64 2044959 - Genes Dev. 1991 Jun;5(6):908-18 16155013 - J Clin Oncol. 2005 Sep 10;23(26):6306-15 12616481 - Eur J Immunol. 2003 Mar;33(3):606-15 8643464 - Proc Natl Acad Sci U S A. 1996 May 14;93(10):4683-7 12479821 - Immunity. 2002 Dec;17(6):749-56 M Tremblay (ref34) 2010; 24 (ref49); 7 MR Kamstrup (ref51) 2008; 158 TM Schmitt (ref19) 2002; 17 L Nie (ref44) 2008; 283 W Swat (ref30) 1996; 93 DJ Izon (ref18) 2001; 14 XK Zhang (ref29) 2008; 181 Y Yashiro-Ohtani (ref43) 2009; 23 SA Armstrong (ref40) 2005; 23 R Jeannet (ref24) 2010; 116 AL Folpe (ref53) 2000; 24 G Bain (ref35) 1997; 17 FE Craig (ref25) 2008; 111 PJ Grohar (ref55) 2011; 103 AP Weng (ref27) 2004; 306 AM Kruisbeek (ref15) 2000; 21 R Pereira (ref26) 1999; 18 RG Hawley (ref31) 1995; 11 M Masuya (ref5) 2005; 105 MK Anderson (ref6) 1999; 126 TD Ashworth (ref23) 2010; 116 J O’Neil (ref28) 2006; 107 M Miyazaki (ref45) 2011; 12 P Mhawech-Fauceglia (ref54) 2007; 60 H Kawada (ref3) 2001; 73 G Anderson (ref8) 2000; 12 T Palomero (ref42) 2006; 108 O Delattre (ref2) 1994; 331 JR Gothert (ref36) 2007; 110 TS Heng (ref48) 2008; 9 H Wada (ref13) 2008; 452 J O’Neil (ref41) 2004; 5 J Starck (ref4) 2010; 116 YW Lin (ref22) 2006; 107 F Liu (ref37) 2008; 18 A Wilson (ref16) 1989; 1 H Feng (ref38) 2010; 18 G Balciunaite (ref11) 2005; 105 H Kawamoto (ref17) 2003; 33 L Wu (ref10) 1996; 184 DI Godfrey (ref14) 1994; 152 EM Mercer (ref46) 2011; 35 JR Carlyle (ref9) 1997; 186 PW Laird (ref20) 1991; 19 Y-J Li (ref56) 2012; 2 L Zhang (ref7) 1995; 15 I Engel (ref39) 2004; 23 CM Quick (ref52) 2006; 33 EJ Reschly (ref47) 2006; 107 JJ Bell (ref12) 2008; 452 F Gartner (ref21) 1999; 10 S Winandy (ref32) 1995; 83 KM Abraham (ref33) 1991; 88 Y Ben-David (ref1) 1991; 5 JE Haydu (ref50) 2012; 119
References_xml	– volume: 5 start-page: 908 year: 1991 ident: ref1 article-title: Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1, closely linked to c-ets-1 publication-title: Genes Dev doi: 10.1101/gad.5.6.908 contributor: fullname: Y Ben-David – volume: 186 start-page: 173 year: 1997 ident: ref9 article-title: Identification of a novel developmental stage marking lineage commitment of progenitor thymocytes publication-title: J Exp Med doi: 10.1084/jem.186.2.173 contributor: fullname: JR Carlyle – volume: 14 start-page: 253 year: 2001 ident: ref18 article-title: Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength publication-title: Immunity doi: 10.1016/S1074-7613(01)00107-8 contributor: fullname: DJ Izon – volume: 283 start-page: 684 year: 2008 ident: ref44 article-title: Ubiquitination and degradation of Tal1/SCL are induced by notch signaling and depend on Skp2 and CHIP publication-title: J Biol Chem doi: 10.1074/jbc.M704981200 contributor: fullname: L Nie – volume: 126 start-page: 3131 year: 1999 ident: ref6 article-title: Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage publication-title: Development doi: 10.1242/dev.126.14.3131 contributor: fullname: MK Anderson – volume: 116 start-page: 5443 year: 2010 ident: ref24 article-title: Oncogenic activation of the Notch1 gene by deletion of its promoter in Ikaros-deficient T-ALL publication-title: Blood doi: 10.1182/blood-2010-05-286658 contributor: fullname: R Jeannet – volume: 1 start-page: 605 year: 1989 ident: ref16 article-title: The acquisition of CD4 and CD8 during the differentiation of early thymocytes in short-term culture publication-title: Int Immunol doi: 10.1093/intimm/1.6.605 contributor: fullname: A Wilson – volume: 33 start-page: 606 year: 2003 ident: ref17 article-title: Extensive proliferation of T cell lineage-restricted progenitors in the thymus: an essential process for clonal expression of diverse T cell receptor beta chains publication-title: Eur J Immunol doi: 10.1002/eji.200323461 contributor: fullname: H Kawamoto – volume: 24 start-page: 1657 year: 2000 ident: ref53 article-title: Immunohistochemical detection of FLI-1 protein expression: a study of 132 round cell tumors with emphasis on CD99-positive mimics of Ewing’s sarcoma/primitive neuroectodermal tumor publication-title: Am J Surg Pathol doi: 10.1097/00000478-200012000-00010 contributor: fullname: AL Folpe – volume: 18 start-page: 1597 year: 1999 ident: ref26 article-title: FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts publication-title: Oncogene doi: 10.1038/sj.onc.1202534 contributor: fullname: R Pereira – volume: 23 start-page: 6306 year: 2005 ident: ref40 article-title: Molecular genetics of acute lymphoblastic leukemia publication-title: J Clin Oncol doi: 10.1200/JCO.2005.05.047 contributor: fullname: SA Armstrong – volume: 107 start-page: 781 year: 2006 ident: ref28 article-title: Activating Notch1 mutations in mouse models of T-ALL publication-title: Blood doi: 10.1182/blood-2005-06-2553 contributor: fullname: J O’Neil – volume: 158 start-page: 747 year: 2008 ident: ref51 article-title: Potential involvement of Notch1 signalling in the pathogenesis of primary cutaneous CD30-positive lymphoproliferative disorders publication-title: Br J Dermatol doi: 10.1111/j.1365-2133.2007.08427.x contributor: fullname: MR Kamstrup – volume: 18 start-page: 353 year: 2010 ident: ref38 article-title: T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation publication-title: Cancer Cell doi: 10.1016/j.ccr.2010.09.009 contributor: fullname: H Feng – volume: 15 start-page: 6961 year: 1995 ident: ref7 article-title: An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes publication-title: Mol Cell Biol doi: 10.1128/MCB.15.12.6961 contributor: fullname: L Zhang – volume: 152 start-page: 4783 year: 1994 ident: ref14 article-title: Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation publication-title: J Immunol doi: 10.4049/jimmunol.152.10.4783 contributor: fullname: DI Godfrey – volume: 7 start-page: 532 ident: ref49 article-title: Wilson NK, Foster SD, Wang X, Knezevic K, Schutte J, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators publication-title: Cell Stem Cell doi: 10.1016/j.stem.2010.07.016 – volume: 23 start-page: 202 year: 2004 ident: ref39 article-title: E2A proteins enforce a proliferation checkpoint in developing thymocytes publication-title: EMBO J doi: 10.1038/sj.emboj.7600017 contributor: fullname: I Engel – volume: 93 start-page: 4683 year: 1996 ident: ref30 article-title: Activated Ras signals differentiation and expansion of CD4+8+ thymocytes publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.93.10.4683 contributor: fullname: W Swat – volume: 111 start-page: 3941 year: 2008 ident: ref25 article-title: Flow cytometric immunophenotyping for hematologic neoplasms publication-title: Blood doi: 10.1182/blood-2007-11-120535 contributor: fullname: FE Craig – volume: 108 start-page: 986 year: 2006 ident: ref42 article-title: Transcriptional regulatory networks downstream of TAL1/SCL in T-cell acute lymphoblastic leukemia publication-title: Blood doi: 10.1182/blood-2005-08-3482 contributor: fullname: T Palomero – volume: 33 start-page: 642 year: 2006 ident: ref52 article-title: Fli-1 expression in mycosis fungoides publication-title: J Cutan Pathol doi: 10.1111/j.1600-0560.2006.00535.x contributor: fullname: CM Quick – volume: 119 start-page: 5211 year: 2012 ident: ref50 article-title: An activating intragenic deletion in NOTCH1 in human T-ALL publication-title: Blood doi: 10.1182/blood-2011-10-388504 contributor: fullname: JE Haydu – volume: 18 start-page: 1234 year: 2008 ident: ref37 article-title: Fli1 acts at the top of the transcriptional network driving blood and endothelial development publication-title: Curr Biol doi: 10.1016/j.cub.2008.07.048 contributor: fullname: F Liu – volume: 9 start-page: 1091 year: 2008 ident: ref48 article-title: The Immunological Genome Project: networks of gene expression in immune cells publication-title: Nat Immunol doi: 10.1038/ni1008-1091 contributor: fullname: TS Heng – volume: 60 start-page: 694 year: 2007 ident: ref54 article-title: Friend leukaemia integration-1 expression in malignant and benign tumours: a multiple tumour tissue microarray analysis using polyclonal antibody publication-title: J Clin Pathol doi: 10.1136/jcp.2006.039230 contributor: fullname: P Mhawech-Fauceglia – volume: 105 start-page: 95 year: 2005 ident: ref5 article-title: Dysregulation of granulocyte, erythrocyte, and NK cell lineages in Fli-1 gene-targeted mice publication-title: Blood doi: 10.1182/blood-2003-12-4345 contributor: fullname: M Masuya – volume: 181 start-page: 1644 year: 2008 ident: ref29 article-title: The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice publication-title: J Immunol doi: 10.4049/jimmunol.181.3.1644 contributor: fullname: XK Zhang – volume: 116 start-page: 4795 year: 2010 ident: ref4 article-title: Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation publication-title: Blood doi: 10.1182/blood-2010-02-270405 contributor: fullname: J Starck – volume: 19 start-page: 4293 year: 1991 ident: ref20 article-title: Simplified mammalian DNA isolation procedure publication-title: Nucleic Acids Res doi: 10.1093/nar/19.15.4293 contributor: fullname: PW Laird – volume: 452 start-page: 768 year: 2008 ident: ref13 article-title: Adult T-cell progenitors retain myeloid potential publication-title: Nature doi: 10.1038/nature06839 contributor: fullname: H Wada – volume: 306 start-page: 269 year: 2004 ident: ref27 article-title: Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia publication-title: Science doi: 10.1126/science.1102160 contributor: fullname: AP Weng – volume: 2 start-page: 1 year: 2012 ident: ref56 article-title: Drug-mediated inhibition of Fli-1 for the treatment of leukemia publication-title: Blood Cancer Journal contributor: fullname: Y-J Li – volume: 331 start-page: 294 year: 1994 ident: ref2 article-title: The Ewing family of tumors–a subgroup of small-round-cell tumors defined by specific chimeric transcripts publication-title: N Engl J Med doi: 10.1056/NEJM199408043310503 contributor: fullname: O Delattre – volume: 24 start-page: 1093 year: 2010 ident: ref34 article-title: Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes publication-title: Genes Dev doi: 10.1101/gad.1897910 contributor: fullname: M Tremblay – volume: 73 start-page: 463 year: 2001 ident: ref3 article-title: Defective megakaryopoiesis and abnormal erythroid development in Fli-1 gene-targeted mice publication-title: Int J Hematol doi: 10.1007/BF02994008 contributor: fullname: H Kawada – volume: 12 start-page: 457 year: 2000 ident: ref8 article-title: Microenvironmental regulation of T cell development in the thymus publication-title: Semin Immunol doi: 10.1006/smim.2000.0260 contributor: fullname: G Anderson – volume: 184 start-page: 903 year: 1996 ident: ref10 article-title: Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny publication-title: J Exp Med doi: 10.1084/jem.184.3.903 contributor: fullname: L Wu – volume: 11 start-page: 1113 year: 1995 ident: ref31 article-title: Hematopoietic transforming potential of activated ras in chimeric mice publication-title: Oncogene contributor: fullname: RG Hawley – volume: 17 start-page: 749 year: 2002 ident: ref19 article-title: Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro publication-title: Immunity doi: 10.1016/S1074-7613(02)00474-0 contributor: fullname: TM Schmitt – volume: 452 start-page: 764 year: 2008 ident: ref12 article-title: The earliest thymic progenitors for T cells possess myeloid lineage potential publication-title: Nature doi: 10.1038/nature06840 contributor: fullname: JJ Bell – volume: 5 start-page: 587 year: 2004 ident: ref41 article-title: TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB publication-title: Cancer Cell doi: 10.1016/j.ccr.2004.05.023 contributor: fullname: J O’Neil – volume: 88 start-page: 3977 year: 1991 ident: ref33 article-title: Thymic tumorigenesis induced by overexpression of p56lck publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.88.9.3977 contributor: fullname: KM Abraham – volume: 116 start-page: 5455 year: 2010 ident: ref23 article-title: Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1 publication-title: Blood doi: 10.1182/blood-2010-05-286328 contributor: fullname: TD Ashworth – volume: 110 start-page: 3753 year: 2007 ident: ref36 article-title: NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis publication-title: Blood doi: 10.1182/blood-2006-12-063644 contributor: fullname: JR Gothert – volume: 17 start-page: 4782 year: 1997 ident: ref35 article-title: E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas publication-title: Mol Cell Biol doi: 10.1128/MCB.17.8.4782 contributor: fullname: G Bain – volume: 35 start-page: 413 year: 2011 ident: ref46 article-title: Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors publication-title: Immunity doi: 10.1016/j.immuni.2011.06.013 contributor: fullname: EM Mercer – volume: 10 start-page: 537 year: 1999 ident: ref21 article-title: Immature thymocytes employ distinct signaling pathways for allelic exclusion versus differentiation and expansion publication-title: Immunity doi: 10.1016/S1074-7613(00)80053-9 contributor: fullname: F Gartner – volume: 83 start-page: 289 year: 1995 ident: ref32 article-title: A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma publication-title: Cell doi: 10.1016/0092-8674(95)90170-1 contributor: fullname: S Winandy – volume: 107 start-page: 4115 year: 2006 ident: ref47 article-title: Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms publication-title: Blood doi: 10.1182/blood-2005-09-3551 contributor: fullname: EJ Reschly – volume: 107 start-page: 2540 year: 2006 ident: ref22 article-title: Notch1 mutations are important for leukemic transformation in murine models of precursor-T leukemia/lymphoma publication-title: Blood doi: 10.1182/blood-2005-07-3013 contributor: fullname: YW Lin – volume: 12 start-page: 992 year: 2011 ident: ref45 article-title: The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells publication-title: Nat Immunol doi: 10.1038/ni.2086 contributor: fullname: M Miyazaki – volume: 21 start-page: 637 year: 2000 ident: ref15 article-title: Branching out to gain control: how the pre-TCR is linked to multiple functions publication-title: Immunol Today doi: 10.1016/S0167-5699(00)01744-8 contributor: fullname: AM Kruisbeek – volume: 23 start-page: 1665 year: 2009 ident: ref43 article-title: Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A publication-title: Genes Dev doi: 10.1101/gad.1793709 contributor: fullname: Y Yashiro-Ohtani – volume: 103 start-page: 962 year: 2011 ident: ref55 article-title: Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening publication-title: J Natl Cancer Inst doi: 10.1093/jnci/djr156 contributor: fullname: PJ Grohar – volume: 105 start-page: 1930 year: 2005 ident: ref11 article-title: The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential publication-title: Blood doi: 10.1182/blood-2004-08-3087 contributor: fullname: G Balciunaite
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Snippet	The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but the role of Fli-1 in T cell... The Ets transcription factor Fli-1 is preferentially expressed in hematopoietic tissues and cells, including immature T cells, but the role of Fli-1 in T cell...
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SubjectTerms	Animals Apoptosis B cells Bcl-2 protein Biology Bone marrow Cancer Carcinogenesis - immunology CD4 antigen CD8 antigen Deregulation ETS protein FLI-1 protein Flow cytometry Gene Expression Genes Genomes Hematology Hematopoietic Stem Cells - metabolism Hemopoiesis Humans Immunoglobulins Immunology Intracellular Space - genetics Leukemia Liver transplants Lymphatic system Lymphocytes Lymphocytes T Lymphoma Medicine Mice Mice, Inbred C57BL Mutation Notch1 protein Organ Specificity Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - immunology Precursor B-Cell Lymphoblastic Leukemia-Lymphoma - pathology Proto-Oncogene Protein c-fli-1 - genetics Proto-Oncogene Proteins c-bcl-2 - genetics Receptor, Notch1 - genetics RNA, Messenger - genetics Signal transduction Signaling Spleen Stem cell transplantation T cell receptors T cells T-Lymphocytes - cytology T-Lymphocytes - immunology Target recognition Tissues Transcription factors Tumors Up-Regulation - immunology
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Title	Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma
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