Predictive factors for missed adenoma on repeat colonoscopy in patients with suboptimal bowel preparation on initial colonoscopy: A KASID multicenter study

• Published in: PloS one Vol. 13; no. 4; p. e0195709
• Main Authors: Chang, Ji Young, Moon, Chang Mo, Lee, Hyun Jung, Yang, Hyo-Joon, Jung, Yunho, Kim, Sang Wook, Jung, Sung-Ae, Byeon, Jeong-Sik
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26-04-2018; Public Library of Science (PLoS)
• Subjects: Adenoma; Adenoma - complications; Adenoma - diagnosis; Adult; Aged; Biology and Life Sciences; Cancer research; Care and treatment; Cathartics; Colon; Colonic Polyps - diagnosis; Colonoscopy; Colonoscopy - statistics & numerical data; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - complications; Colorectal Neoplasms - diagnosis; Confidence intervals; Dyslipidemia; Dyslipidemias - complications; False Negative Reactions; Female; Gastroenterology; Humans; Internal medicine; Intestine; Lesions; Male; Medicine; Medicine and Health Sciences; Metabolic disorders; Middle Aged; Patients; Retrospective Studies; Risk analysis; Risk Factors; Studies; Surveillance; Therapeutic Irrigation; Tumors; South Korea; Japan
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0195709

Suboptimal bowel preparation can result in missed colorectal adenoma that can evolve into interval colorectal cancer. This study aims to identify the predictive factors associated with missed adenoma on repeat colonoscopy in patients with suboptimal bowel preparation at initial colonoscopy. A total of 441 patients with suboptimal bowel preparation on initial colonoscopy and who had repeat colonoscopy within two years were included from 2007 to 2014 in six tertiary hospitals. Suboptimal bowel preparation was defined as 'poor' according to the Aronchick scale or a score ≤ 1 in at least one segment or total score < 6 according to the Boston bowel preparation scale. Of 441 patients, mean age at initial colonoscopy was 59.1 years, and 69.2% patients were male. The mean interval from initial to repeat colonoscopy was 14.1 months. The per-patient adenoma miss rate (AMR) was 42.4% for any adenoma and 5.4% for advanced adenoma. When the association between baseline clinical characteristics and missed lesions on repeat colonoscopy was analyzed, dyslipidemia (odds ratio [OR], 5.19; 95% confidence interval [CI], 1.14-23.66; P = 0.034), and high-risk adenoma (OR, 4.45; 95% CI, 1.12-17.68; P = 0.034) on initial colonoscopy were independent risk factors for missed advanced adenoma. In patients with suboptimal bowel preparation, dyslipidemia and high-risk adenoma on initial colonoscopy were independently predictive of missed advanced adenoma on repeat colonoscopy.