Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients

• Published in: PloS one Vol. 13; no. 3; p. e0191059
• Main Authors: Horndasch, Stefanie, Roesch, Julie, Forster, Clemens, Dörfler, Arnd, Lindsiepe, Silja, Heinrich, Hartmut, Graap, Holmer, Moll, Gunther H, Kratz, Oliver
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26-03-2018; Public Library of Science (PLoS)
• Subjects: Activation; Adolescents; Adults; Anorexia; Anorexia nervosa; Biology and Life Sciences; Brain; Brain mapping; Child development; Data analysis; Data processing; Development and progression; Eating behavior; Eating disorders; Emotions; Food; Food processing; Functional magnetic resonance imaging; Hedonic response; Image processing; Information processing; Magnetic resonance; Magnetic resonance imaging; Medicine and Health Sciences; Mental disorders; Mental health; Neural circuitry; Neuroimaging; Patients; People and Places; Pictures; Psychiatry; Psychological research; Psychophysiology; Reinforcement; Research and Analysis Methods; Social Sciences; Stimuli; Stimuli (Psychology); Studies; Teenagers; Germany
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0191059

A constant preoccupation with food and restrictive eating are main symptoms of anorexia nervosa (AN). Imaging studies revealed aberrant neural activation patterns in brain regions processing hedonic and reward reactions as well as-potentially aversive-emotions. An imbalance between so called "bottom-up" and "top-down" control areas is discussed. The present study is focusing on neural processing of disease-specific food stimuli and emotional stimuli and its developmental course in adolescent and adult AN patients and could offer new insight into differential mechanisms underlying shorter or more chronic disease.
33 adolescents aged 12-18 years (15 AN patients, 18 control participants) and 32 adult women (16 AN patients, 16 control participants) underwent functional magnetic resonance imaging (fMRI, 3T high-field scanner) while watching pictures of high and low-calorie food and affective stimuli. Afterwards, they rated subjective valence of each picture. FMRI data analysis was performed using a region of interest based approach.
Pictures of high-calorie food items were rated more negatively by AN patients. Differences in activation between patients and controls were found in "bottom up" and "top down" control areas for food stimuli and in several emotion processing regions for affective stimuli which were more pronounced in adolescents than in adults.
A differential pattern was seen for food stimuli compared to generally emotion eliciting stimuli. Adolescents with AN show reduced processing of affective stimuli and enhanced activation of regions involved in "bottom up" reward processing and "top down" control as well as the insula with regard to food stimuli with a focus on brain regions which underlie changes during adolescent development. In adults less clear and less specific activation differences were present, pointing towards a high impact that regions undergoing maturation might have on AN symptoms.