Second-hand cigarette smoke impairs bacterial phagocytosis in macrophages by modulating CFTR dependent lipid-rafts

First/Second-hand cigarette-smoke (FHS/SHS) exposure weakens immune defenses inducing chronic obstructive pulmonary disease (COPD) but the underlying mechanisms are not fully understood. Hence, we evaluated if SHS induced changes in membrane/lipid-raft (m-/r)-CFTR (cystic fibrosis transmembrane cond...

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Bibliographic Details
Published in:	PloS one Vol. 10; no. 3; p. e0121200
Main Authors:	Ni, Inzer, Ji, Changhoon, Vij, Neeraj
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 20-03-2015 Public Library of Science (PLoS)
Subjects:	Animal models Animals Bacteria Bacterial infections Biomedical engineering Cell culture Cell Survival Chronic obstructive lung disease Chronic obstructive pulmonary disease Cigarette smoke Cigarettes Conductance Culture media Cystic fibrosis Cystic Fibrosis Transmembrane Conductance Regulator - metabolism Emphysema Experiments Exposure Fibrosis Fluorescence Health aspects Immunoblotting Inducers Infection Infections Lipid rafts Lipids Lung diseases Lungs Macrophages Macrophages - cytology Macrophages - drug effects Macrophages - microbiology Media (culture) Medicine Membrane Microdomains - metabolism Mice Microscopy Mutation Obstructive lung disease Pathogenesis Pediatrics Phagocytosis Phagocytosis - drug effects Pseudomonas aeruginosa Rafts RAW 264.7 Cells Resistance Rodents Smoke Smoking Survival Synergistic effect Tobacco Smoke Pollution - adverse effects Transfection United States > US Maryland Baltimore Maryland
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