Metabolomics and in-silico analysis reveal critical energy deregulations in animal models of Parkinson's disease

Parkinson's disease (PD) is a multifactorial disease known to result from a variety of factors. Although age is the principal risk factor, other etiological mechanisms have been identified, including gene mutations and exposure to toxins. Deregulation of energy metabolism, mostly through the lo...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 7; p. e69146
Main Authors:	Poliquin, Pierre O, Chen, Jingkui, Cloutier, Mathieu, Trudeau, Louis-Éric, Jolicoeur, Mario
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 23-07-2013 Public Library of Science (PLoS)
Subjects:	Adenosine triphosphate Analysis Animal models Animals Biology Brain Brain - drug effects Brain - metabolism Brain - pathology Brain research Brain slice preparation Carbonyl Cyanide m-Chlorophenyl Hydrazone - toxicity Chemical engineering Computer Science Computer Simulation Control engineering Data analysis Data processing Deregulation Disease Models, Animal Dopamine Energy Energy metabolism Energy Metabolism - drug effects Engineering Etiology Exposure Gene mutation Genes Genetic aspects Homeostasis Information management Mathematical analysis Mathematical models Mathematics Medical research Medicine Metabolic pathways Metabolism Metabolites Metabolomics Mice Mice, Knockout Movement disorders Mutation Neurodegenerative diseases Neurosciences Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Pathogenesis Pathways Proteins Quality control Regulation Respiration Risk factors Robustness (mathematics) Stress, Physiological - drug effects Studies Toxins Ubiquitin-Protein Ligases - deficiency Ubiquitin-Protein Ligases - genetics Canada Quebec Canada
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